{"id":"W2724881933","doi":"10.1038/s41467-017-00057-x","title":"Endosomal NOX2 oxidase exacerbates virus pathogenicity and is a target for antiviral therapy","year":2017,"lang":"en","type":"article","venue":"Nature Communications","topic":"Neutrophil, Myeloperoxidase and Oxidative Mechanisms","field":"Immunology and Microbiology","cited_by":153,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Institute of Infection and Immunity; Australian Research Council; ARC Centre for Excellence in Convergent Bio-Nano Science and Technology; Medical Research Council; National Health and Medical Research Council; Hudson Institute of Medical Research; RMIT University; Monash University; Deakin University; University of Melbourne; Commonwealth Scientific and Industrial Research Organisation","keywords":"Endosome; Pathogenicity; Virology; Virus; NADPH oxidase; Antiviral therapy; Biology; Medicine; Cell biology; Reactive oxygen species; Receptor; Genetics; Microbiology","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["sts"],"consensus_categories":[],"category_scores_codex":[0.000233429,0.0002161131,0.0002781982,0.00006726194,0.001916719,0.00008707275,0.001274126,0.0004491762,0.00008112202],"category_scores_gemma":[0.0001654025,0.0001828743,0.000122025,0.00004693367,0.0004832095,0.0002278942,0.0005000719,0.0007236131,0.0000557114],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001714178,"about_ca_system_score_gemma":0.00004314132,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00004557812,"about_ca_topic_score_gemma":0.0001080567,"domain_scores_codex":[0.9989717,0.0001844165,0.0002018706,0.000317706,0.00003171164,0.0002925667],"domain_scores_gemma":[0.9972552,0.0002766657,0.0002048499,0.002082377,0.0001522645,0.0000286162],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001235485,0.0001765629,0.001517797,0.000005378789,0.0001384895,0.000001209749,0.0002988024,2.624863e-8,0.9716962,0.01624785,0.002404673,0.007389489],"study_design_scores_gemma":[0.001775367,0.0001889634,0.01056506,0.00001715208,0.00003196115,0.00001364144,0.00006119717,0.00001145057,0.7537246,0.00222022,0.2311618,0.0002285392],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9556913,0.03334175,0.0002671943,0.006611189,0.0004236455,0.0009056358,0.001124572,0.0001015331,0.001533109],"genre_scores_gemma":[0.9902557,0.003098524,0.004421643,0.001062479,0.00003964646,0.0001466662,0.0002673656,0.00002526884,0.0006826728],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2287571,"threshold_uncertainty_score":0.9993827,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03363434913382222,"score_gpt":0.3096403288505631,"score_spread":0.2760059797167408,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}