{"id":"W2724917816","doi":"10.1021/jacs.7b04885","title":"Freezing Directed Construction of Bio/Nano Interfaces: Reagentless Conjugation, Denser Spherical Nucleic Acids, and Better Nanoflares","year":2017,"lang":"en","type":"article","venue":"Journal of the American Chemical Society","topic":"Advanced biosensing and bioanalysis techniques","field":"Biochemistry, Genetics and Molecular Biology","cited_by":517,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Waterloo","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"Chemistry; Colloidal gold; Nucleic acid; Nanomaterials; DNA; Nanotechnology; Polymer; Nanoparticle; Salt (chemistry); Conjugated system; Chemical engineering; Reagent; Polylactic acid; Organic chemistry; Biochemistry; Materials science","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001381305,0.0001063309,0.0002538783,0.000007846779,0.0001301005,0.00003171678,0.0002700442,0.00007586954,0.000001380057],"category_scores_gemma":[0.0001701153,0.00006855983,0.0002387489,0.00005862839,0.001186647,0.000009650968,0.0001749534,0.0001336412,8.975545e-8],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002092146,"about_ca_system_score_gemma":0.00002455764,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001836681,"about_ca_topic_score_gemma":0.000001815103,"domain_scores_codex":[0.9992818,0.00004251465,0.0002826162,0.0001407473,0.0001412557,0.0001110198],"domain_scores_gemma":[0.9984587,0.00001674363,0.001004256,0.0002799513,0.0001943985,0.00004599367],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005102436,0.00002111806,0.01575297,0.000007048399,0.0001403133,3.120461e-7,0.00002709157,3.492667e-7,0.9792923,0.000001251721,0.001180423,0.00352584],"study_design_scores_gemma":[0.0001851169,0.00007503155,0.00302232,0.00004086413,0.0000681466,0.00004035415,0.0001935375,0.00001582978,0.9952594,0.00008208532,0.0009288095,0.00008851813],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9984998,0.00009044963,0.0005586406,0.0007318548,0.00004760391,0.00003436098,0.000006631235,0.000006531364,0.00002417413],"genre_scores_gemma":[0.9681349,0.0003095755,0.03113686,0.0002507241,0.0001314932,4.030832e-7,0.000002163467,0.000009144694,0.00002472026],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03057822,"threshold_uncertainty_score":0.4372249,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00757650062403752,"score_gpt":0.2582012409146042,"score_spread":0.2506247402905667,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}