{"id":"W2724917816","doi":"10.1021/jacs.7b04885","title":"Freezing Directed Construction of Bio/Nano Interfaces: Reagentless Conjugation, Denser Spherical Nucleic Acids, and Better Nanoflares","year":2017,"lang":"en","type":"article","venue":"Journal of the American Chemical Society","topic":"Advanced biosensing and bioanalysis techniques","field":"Biochemistry, Genetics and Molecular Biology","cited_by":517,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Waterloo","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"Chemistry; Colloidal gold; Nucleic acid; Nanomaterials; DNA; Nanotechnology; Polymer; Nanoparticle; Salt (chemistry); Conjugated system; Chemical engineering; Reagent; Polylactic acid; Organic chemistry; Biochemistry; Materials science","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002864723,0.0004054306,0.0002107026,0.0002328719,0.0001379667,0.0002745842,0.0002806791,0.0003366913,0.0003778395],"category_scores_gemma":[0.0003802856,0.0002119428,0.000238931,0.0001058817,0.0002271352,0.0004159721,0.0002738673,0.0004248846,0.0001937072],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002731976,"about_ca_system_score_gemma":0.0001419734,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002129448,"about_ca_topic_score_gemma":0.0003815443,"domain_scores_codex":[0.9998686,0.00001607244,0.00001873344,0.00003277509,0.00004274356,0.00002097506],"domain_scores_gemma":[0.9998086,0.00003916875,0.00006128095,0.00002718387,0.00004367781,0.00002023519],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00000518578,0.000004946947,0.00003080669,0.00001451337,0.000001754721,0.00001195322,0.0000138792,0.00007986557,0.9987494,0.00009551395,0.00001234595,0.0009797876],"study_design_scores_gemma":[0.000001496083,0.00001813304,0.0001920904,0.000001159581,0.000002759938,0.00002326089,0.000003845735,0.000526743,0.9988793,0.00002303947,0.0003259335,0.000002241025],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9206576,0.0007461903,0.07621116,0.0001524045,0.00008019992,0.0001076134,0.0001769706,0.0004033057,0.001464565],"genre_scores_gemma":[0.9245228,0.0006640173,0.07238346,0.0001330817,0.00002043903,0.00009997464,0.0002936634,0.0001179016,0.001764837],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0004054306,"threshold_uncertainty_score":0.001982212,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00757650062403752,"score_gpt":0.2582012409146042,"score_spread":0.2506247402905667,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}