{"id":"W2724938313","doi":"10.1038/nature22969","title":"Fine-mapping inflammatory bowel disease loci to single-variant resolution","year":2017,"lang":"en","type":"article","venue":"Nature","topic":"Inflammatory Bowel Disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":644,"is_retracted":false,"has_abstract":false,"ca_institutions":"Montreal Heart Institute","funders":"National Institute of Dental and Craniofacial Research; National Institute of Allergy and Infectious Diseases; National Cancer Institute; Canadian Institutes of Health Research; Walloon excellence in life sciences and biotechnology; Exzellenzclusters Entzündungsforschung; Fonds Léon Fredericq; Vetenskapsrådet; Deutsche Forschungsgemeinschaft; Fédération Wallonie-Bruxelles; Crohn's and Colitis UK; Fonds De La Recherche Scientifique - FNRS; Belgian Federal Science Policy Office; Universitetssjukhuset Örebro; King's College London; Génome Québec; European Commission; Kennedy Trust for Rheumatology Research; Crohn's and Colitis Foundation; Wellcome Trust; Bundesministerium für Bildung und Forschung; National Institute for Health and Care Research; National Institute of Diabetes and Digestive and Kidney Diseases; Örebro Universitet; Medical Research Council; Leona M. and Harry B. Helmsley Charitable Trust; Crohn's and Colitis Foundation of America; Genome Canada; University of Pittsburgh","keywords":"Inflammatory bowel disease; Inflammatory Bowel Diseases; Resolution (logic); Computational biology; Genetics; Biology; Disease; Medicine; Computer science; Pathology; Artificial intelligence","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001783733,0.000197446,0.00009629911,0.00005383706,0.000411715,0.0001244227,0.0005051977,0.0007301102,0.00002651547],"category_scores_gemma":[0.000884225,0.0002008027,0.0001189385,0.00002702957,0.00007766358,0.000013994,0.0003136132,0.0005115831,0.00007834046],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004304354,"about_ca_system_score_gemma":0.0001534001,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000002942701,"about_ca_topic_score_gemma":0.00006505391,"domain_scores_codex":[0.9987915,0.00004730869,0.0001744988,0.0004438348,0.0002172652,0.0003256511],"domain_scores_gemma":[0.9981975,0.000004513551,0.0001291468,0.001166019,0.0001484573,0.0003543421],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.002951687,0.0003626886,0.1186558,0.0004431891,0.0002539847,0.003677095,0.0002819372,0.001199739,0.6362301,0.003886722,0.2266254,0.005431671],"study_design_scores_gemma":[0.0006581124,0.00003983439,0.7995926,0.00006955533,0.00002879671,0.000007793783,0.00001692022,0.0001790598,0.00563254,0.0001803861,0.1931829,0.0004114975],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9935591,0.0006150335,0.0004238369,0.001596911,0.0005307611,0.0003453497,0.00007607051,0.00004144388,0.002811449],"genre_scores_gemma":[0.9960092,0.000008095721,0.000454569,0.001169038,0.0009213361,0.00003238755,0.0001428607,0.00003328363,0.001229245],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.6809368,"threshold_uncertainty_score":0.8188496,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008339090466473513,"score_gpt":0.2447632767932945,"score_spread":0.2364241863268209,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}