{"id":"W2724938313","doi":"10.1038/nature22969","title":"Fine-mapping inflammatory bowel disease loci to single-variant resolution","year":2017,"lang":"en","type":"article","venue":"Nature","topic":"Inflammatory Bowel Disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":644,"is_retracted":false,"has_abstract":false,"ca_institutions":"Montreal Heart Institute","funders":"National Institute of Dental and Craniofacial Research; National Institute of Allergy and Infectious Diseases; National Cancer Institute; Canadian Institutes of Health Research; Walloon excellence in life sciences and biotechnology; Exzellenzclusters Entzündungsforschung; Fonds Léon Fredericq; Vetenskapsrådet; Deutsche Forschungsgemeinschaft; Fédération Wallonie-Bruxelles; Crohn's and Colitis UK; Fonds De La Recherche Scientifique - FNRS; Belgian Federal Science Policy Office; Universitetssjukhuset Örebro; King's College London; Génome Québec; European Commission; Kennedy Trust for Rheumatology Research; Crohn's and Colitis Foundation; Wellcome Trust; Bundesministerium für Bildung und Forschung; National Institute for Health and Care Research; National Institute of Diabetes and Digestive and Kidney Diseases; Örebro Universitet; Medical Research Council; Leona M. and Harry B. Helmsley Charitable Trust; Crohn's and Colitis Foundation of America; Genome Canada; University of Pittsburgh","keywords":"Inflammatory bowel disease; Inflammatory Bowel Diseases; Resolution (logic); Computational biology; Genetics; Biology; Disease; Medicine; Computer science; Pathology; Artificial intelligence","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001405479,0.0004329019,0.0007523083,0.001080762,0.0006594565,0.001033577,0.0008606944,0.0009224481,0.003332108],"category_scores_gemma":[0.001687319,0.0005732111,0.0009620948,0.0007233288,0.0006721485,0.0003431629,0.001091333,0.001931711,0.001048993],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003694535,"about_ca_system_score_gemma":0.0002181996,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001561989,"about_ca_topic_score_gemma":0.005672019,"domain_scores_codex":[0.9993621,0.0001368482,0.00004594467,0.0002205893,0.0001475628,0.00008687145],"domain_scores_gemma":[0.9985809,0.0006235883,0.0001731097,0.0004536614,0.00009373402,0.00007505332],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0002380473,0.00007681364,0.009150288,0.0001240961,0.0002780909,0.0004699707,0.0001732351,0.003050277,0.9549681,0.005405141,0.0008989378,0.02516693],"study_design_scores_gemma":[0.0002478382,0.000464017,0.2388952,0.0001316674,0.0008064531,0.005893196,0.0003323996,0.03550305,0.6267748,0.03479015,0.0559954,0.000165855],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.6871583,0.004133266,0.2843829,0.0009244821,0.0003807716,0.0001467917,0.004072468,0.00170669,0.01709422],"genre_scores_gemma":[0.9010197,0.001021873,0.0897967,0.0009666441,0.00007995337,0.0001165924,0.001705704,0.0004841542,0.004808793],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003332108,"threshold_uncertainty_score":0.01114702,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008339090466473513,"score_gpt":0.2447632767932945,"score_spread":0.2364241863268209,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}