{"id":"W2726271291","doi":"10.1021/acs.jmedchem.7b00723","title":"Synthetic Modification within the “RPRL” Region of Apelin Peptides: Impact on Cardiovascular Activity and Stability to Neprilysin and Plasma Degradation","year":2017,"lang":"en","type":"article","venue":"Journal of Medicinal Chemistry","topic":"Apelin-related biomedical research","field":"Medicine","cited_by":41,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"Natural Sciences and Engineering Research Council of Canada; Institut National de la Santé et de la Recherche Médicale; Canadian Institutes of Health Research; Alberta Innovates - Health Solutions","keywords":"Chemistry; Apelin; Neprilysin; Degradation (telecommunications); Metabolic stability; Pharmacology; Biochemistry; Internal medicine; Enzyme; Receptor; In vitro","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002304612,0.0002980269,0.000211595,0.0001071251,0.00009535897,0.0001975066,0.0002454053,0.0003605359,0.001078002],"category_scores_gemma":[0.0004065473,0.00009985877,0.0002450403,0.0001269028,0.0001774033,0.0002493885,0.0001691202,0.0005539823,0.0003379306],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001071387,"about_ca_system_score_gemma":0.000121495,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001431415,"about_ca_topic_score_gemma":0.0001426882,"domain_scores_codex":[0.9998631,0.0000359396,0.00001517332,0.00002929123,0.00002507711,0.00003148297],"domain_scores_gemma":[0.9997978,0.00004616591,0.00007767919,0.00002064311,0.00002337144,0.00003440037],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004368389,0.00004960385,0.00009688946,0.00007522092,0.0000160151,0.0002710897,0.00002781651,0.0002710078,0.9965088,0.0001462901,0.00002971201,0.002070695],"study_design_scores_gemma":[0.00008598231,0.001573348,0.001145149,0.0000139332,0.0000403914,0.000754483,0.0000278343,0.0006094315,0.9923166,0.00007009779,0.003342293,0.00002050127],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9947526,0.001315534,0.002619822,0.0000607367,0.00004037726,0.00003730806,0.0001330706,0.00001853471,0.001022003],"genre_scores_gemma":[0.9944056,0.0009107454,0.003444034,0.00008528384,0.00001646507,0.00002806824,0.0002199397,0.00001689102,0.0008728519],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001078002,"threshold_uncertainty_score":0.003606319,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0517802949200503,"score_gpt":0.3452101660273661,"score_spread":0.2934298711073158,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}