{"id":"W2726391040","doi":"10.1016/j.celrep.2017.06.022","title":"The Ubiquitination of PINK1 Is Restricted to Its Mature 52-kDa Form","year":2017,"lang":"en","type":"article","venue":"Cell Reports","topic":"Ubiquitin and proteasome pathways","field":"Biochemistry, Genetics and Molecular Biology","cited_by":63,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"National Institute of Neurological Disorders and Stroke; National Institute of General Medical Sciences; National Cancer Institute; National Institutes of Health; Parkinson Vereniging; Memorial Sloan-Kettering Cancer Center; American Parkinson Disease Association; U.S. Department of Defense","keywords":"PINK1; Ubiquitin; Parkin; Cell biology; Ubiquitin ligase; Cytosol; Mitochondrion; Lysine; Biology; Chemistry; Biochemistry; Autophagy; Enzyme; Mitophagy; Gene; Amino acid; Medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001932108,0.0001026868,0.00009713804,0.00001925217,0.000304991,0.00006175942,0.0002308639,0.0001414203,0.00002105503],"category_scores_gemma":[0.0003663259,0.00007775543,0.00007133741,0.00003500746,0.00004101095,0.000004705408,0.0001728384,0.00007474553,0.00000886583],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000008200459,"about_ca_system_score_gemma":0.00007345784,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001399249,"about_ca_topic_score_gemma":0.00001369867,"domain_scores_codex":[0.9991461,0.00001783109,0.0002461963,0.000248824,0.0001554308,0.0001856046],"domain_scores_gemma":[0.998463,0.000008749669,0.0003803833,0.000879317,0.0001939514,0.00007461525],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003693453,0.00002522464,0.0007965628,0.00003675569,0.00001279786,0.00002364491,0.000106396,0.000001336734,0.978943,0.00006812853,0.01567814,0.004271063],"study_design_scores_gemma":[0.00008167721,0.00009711483,0.005550822,0.00001442578,0.000006765936,0.00002840169,0.0000198042,0.000004208346,0.8007384,0.0002292372,0.1931458,0.00008334195],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9541175,0.0005855159,0.00007963175,0.0006979628,0.0003261371,0.000365961,0.00001458804,0.00001011996,0.04380259],"genre_scores_gemma":[0.9900104,0.0001526718,0.0001592806,0.0001846491,0.0001703909,0.00002865895,0.00003574326,0.00001480297,0.009243417],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1782046,"threshold_uncertainty_score":0.3170774,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0137845857012622,"score_gpt":0.2600248728196829,"score_spread":0.2462402871184207,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}