{"id":"W2726391040","doi":"10.1016/j.celrep.2017.06.022","title":"The Ubiquitination of PINK1 Is Restricted to Its Mature 52-kDa Form","year":2017,"lang":"en","type":"article","venue":"Cell Reports","topic":"Ubiquitin and proteasome pathways","field":"Biochemistry, Genetics and Molecular Biology","cited_by":63,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"National Institute of Neurological Disorders and Stroke; National Institute of General Medical Sciences; National Cancer Institute; National Institutes of Health; Parkinson Vereniging; Memorial Sloan-Kettering Cancer Center; American Parkinson Disease Association; U.S. Department of Defense","keywords":"PINK1; Ubiquitin; Parkin; Cell biology; Ubiquitin ligase; Cytosol; Mitochondrion; Lysine; Biology; Chemistry; Biochemistry; Autophagy; Enzyme; Mitophagy; Gene; Amino acid; Medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001124106,0.0002266679,0.0002484297,0.0001487968,0.0001755692,0.0004716354,0.0001202945,0.0001308786,0.002002555],"category_scores_gemma":[0.0002149615,0.0001451778,0.0002028571,0.0001764673,0.0001840037,0.000463288,0.0002928464,0.0002457607,0.001035939],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003764681,"about_ca_system_score_gemma":0.0002671655,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003109465,"about_ca_topic_score_gemma":0.0003473657,"domain_scores_codex":[0.9998468,0.00001506456,0.00001281491,0.00006472793,0.00003189424,0.00002860077],"domain_scores_gemma":[0.9998344,0.00001258817,0.00006272754,0.00002828015,0.00002491097,0.00003708044],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006256001,0.000004818215,0.000998595,0.00002617747,0.00000545081,0.00008271691,0.00001489658,0.00004712843,0.9966705,0.0002083171,0.00004437481,0.001834343],"study_design_scores_gemma":[0.00001276762,0.0001706772,0.03133655,0.00001053815,0.00001855554,0.002978447,0.00006470335,0.0006823379,0.9555026,0.0003562946,0.008856214,0.00001030941],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9867402,0.003659418,0.006502899,0.0001506388,0.00001888193,0.000008953351,0.0002886069,0.00006339223,0.002566918],"genre_scores_gemma":[0.9954039,0.0009680701,0.001229522,0.00003883104,0.000005879273,0.000005560818,0.0004090838,0.00001577853,0.001923412],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002002555,"threshold_uncertainty_score":0.006699264,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0137845857012622,"score_gpt":0.2600248728196829,"score_spread":0.2462402871184207,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}