{"id":"W2726418175","doi":"10.1021/acs.biochem.7b00209","title":"Role of Site-Specific Asparagine Deamidation in Islet Amyloid Polypeptide Amyloidogenesis: Key Contributions of Residues 14 and 21","year":2017,"lang":"en","type":"article","venue":"Biochemistry","topic":"Alzheimer's disease research and treatments","field":"Medicine","cited_by":52,"is_retracted":false,"has_abstract":true,"ca_institutions":"PROTEO; Université du Québec à Montréal","funders":"Fonds de recherche du Québec – Nature et technologies; Natural Sciences and Engineering Research Council of Canada","keywords":"Deamidation; Chemistry; Asparagine; Thioflavin; Fibril; Biochemistry; Amyloid (mycology); Circular dichroism; Residue (chemistry); Peptide; Protein folding; Protein aggregation; Protein structure; Aspartic acid; Biophysics; Amino acid; Enzyme","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001067358,0.0001112412,0.000247156,0.00005423437,0.0000745452,0.00001548928,0.00009149745,0.00007586419,0.00004905427],"category_scores_gemma":[0.0001709163,0.000102674,0.00005415824,0.00005460165,0.0002113806,0.00004727907,0.00006237182,0.00007485395,0.000007477751],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004994881,"about_ca_system_score_gemma":0.0001267034,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000278282,"about_ca_topic_score_gemma":0.00001824024,"domain_scores_codex":[0.9991505,0.00001502535,0.0002230652,0.0002082105,0.0002154672,0.0001876896],"domain_scores_gemma":[0.9990212,0.00003348023,0.000148772,0.0004744324,0.0001676095,0.000154544],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003784586,0.0002977586,0.2156051,0.000100485,0.0003491831,0.00002013705,0.0000358876,3.418893e-7,0.7824375,0.00002555933,0.0002532556,0.0004963382],"study_design_scores_gemma":[0.001411819,0.0000490077,0.2512217,0.0001300478,0.00008132821,0.000007122682,0.00005698611,0.00001005222,0.7468343,0.00006866958,0.00007192899,0.00005706987],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9818642,0.0160772,0.000002886944,0.0002471949,0.000008421277,0.0001777824,0.0002938629,0.00001015368,0.001318362],"genre_scores_gemma":[0.9987141,0.000750738,0.0001057552,0.000006496569,0.00005928898,0.00001921497,0.0002376418,0.000009857034,0.00009683396],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03561659,"threshold_uncertainty_score":0.4186925,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01597902746346662,"score_gpt":0.2922796851090468,"score_spread":0.2763006576455802,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}