{"id":"W2726418175","doi":"10.1021/acs.biochem.7b00209","title":"Role of Site-Specific Asparagine Deamidation in Islet Amyloid Polypeptide Amyloidogenesis: Key Contributions of Residues 14 and 21","year":2017,"lang":"en","type":"article","venue":"Biochemistry","topic":"Alzheimer's disease research and treatments","field":"Medicine","cited_by":52,"is_retracted":false,"has_abstract":true,"ca_institutions":"PROTEO; Université du Québec à Montréal","funders":"Fonds de recherche du Québec – Nature et technologies; Natural Sciences and Engineering Research Council of Canada","keywords":"Deamidation; Chemistry; Asparagine; Thioflavin; Fibril; Biochemistry; Amyloid (mycology); Circular dichroism; Residue (chemistry); Peptide; Protein folding; Protein aggregation; Protein structure; Aspartic acid; Biophysics; Amino acid; Enzyme","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002356603,0.0004611405,0.0002370022,0.00008194933,0.0001146098,0.000237837,0.0001500564,0.0002542364,0.0004444731],"category_scores_gemma":[0.0001595123,0.000117378,0.0002244756,0.00006954564,0.0002221762,0.0002001569,0.0001981198,0.0002423054,0.000134193],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001578593,"about_ca_system_score_gemma":0.0001928131,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002692798,"about_ca_topic_score_gemma":0.0002146699,"domain_scores_codex":[0.9998837,0.00002571869,0.0000141708,0.00002781771,0.00002158666,0.00002705937],"domain_scores_gemma":[0.9998708,0.00002235033,0.00004757402,0.00001250762,0.00001727472,0.00002951187],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002561654,0.00003066777,0.0008631537,0.00004249924,0.00001165746,0.0002018354,0.00002362227,0.0001716487,0.9964468,0.00008293196,0.000009137409,0.001859852],"study_design_scores_gemma":[0.00001349539,0.0003655447,0.00585627,0.000006220829,0.00002819851,0.000539835,0.00003170507,0.0008141853,0.9913296,0.00007445681,0.0009334667,0.000006997749],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9969258,0.001325954,0.001044595,0.00002190682,0.000009434934,0.00001475645,0.00002571073,0.0000082626,0.0006236608],"genre_scores_gemma":[0.9979062,0.0007878157,0.0008352337,0.00002146927,0.000003174013,0.000007138221,0.00004746474,0.000005326255,0.0003861157],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0004611405,"threshold_uncertainty_score":0.001486897,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01597902746346662,"score_gpt":0.2922796851090468,"score_spread":0.2763006576455802,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}