{"id":"W2726600314","doi":"10.1534/genetics.117.202291","title":"Connected Gene Communities Underlie Transcriptional Changes in Cornelia de Lange Syndrome","year":2017,"lang":"en","type":"article","venue":"Genetics","topic":"Genomics and Chromatin Dynamics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":28,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université Laval; Centre hospitalier universitaire de Québec","funders":"Canadian Institutes of Health Research; Natural Sciences and Engineering Research Council of Canada; Canada Research Chairs","keywords":"Cohesin; Biology; Genetics; Cornelia de Lange Syndrome; Enhancer; Gene; Regulation of gene expression; Genomic organization; Transcriptional regulation; Chromosome; Gene expression; Genome","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001395943,0.0004141925,0.000220975,0.001045818,0.0002545218,0.0002675874,0.000270276,0.000546233,0.00219826],"category_scores_gemma":[0.0006856635,0.0002143651,0.0002468548,0.0004516515,0.0007426052,0.0002438968,0.0004823198,0.0003855645,0.000177454],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002615045,"about_ca_system_score_gemma":0.0001532657,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007313208,"about_ca_topic_score_gemma":0.0007406785,"domain_scores_codex":[0.9998017,0.00002919789,0.00001490628,0.00005646234,0.00007261478,0.00002519023],"domain_scores_gemma":[0.9995068,0.0001563528,0.0001977074,0.0000254568,0.00002868918,0.000084988],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0007227999,0.0001397106,0.04703406,0.0001135258,0.0001084004,0.02554305,0.0004363159,0.001710876,0.9136391,0.002174584,0.0003800619,0.007997695],"study_design_scores_gemma":[0.0002887278,0.0004532509,0.6219576,0.00008837691,0.0003041439,0.1070828,0.0008328026,0.01747821,0.2360188,0.01129183,0.004098319,0.0001052659],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9971746,0.0002019058,0.001914256,0.00007956736,0.00001204955,0.000009652174,0.0001259645,0.00004766656,0.0004344162],"genre_scores_gemma":[0.9989154,0.00008299768,0.000658131,0.00002302609,0.000007055596,0.000005833112,0.00005111525,0.00001139998,0.0002450938],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00219826,"threshold_uncertainty_score":0.007353902,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02458654591811139,"score_gpt":0.2462119206542709,"score_spread":0.2216253747361596,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}