{"id":"W2726600314","doi":"10.1534/genetics.117.202291","title":"Connected Gene Communities Underlie Transcriptional Changes in Cornelia de Lange Syndrome","year":2017,"lang":"en","type":"article","venue":"Genetics","topic":"Genomics and Chromatin Dynamics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":28,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université Laval; Centre hospitalier universitaire de Québec","funders":"Canadian Institutes of Health Research; Natural Sciences and Engineering Research Council of Canada; Canada Research Chairs","keywords":"Cohesin; Biology; Genetics; Cornelia de Lange Syndrome; Enhancer; Gene; Regulation of gene expression; Genomic organization; Transcriptional regulation; Chromosome; Gene expression; Genome","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001155385,0.0001261171,0.0001234018,0.00003282076,0.0001721066,0.00006438453,0.0004103341,0.0001478918,0.00003063816],"category_scores_gemma":[0.00001367298,0.0001414229,0.00003974263,0.00001741592,0.0001183742,0.000001716413,0.000114609,0.0000891978,0.000007124796],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002512131,"about_ca_system_score_gemma":0.0000651882,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001074207,"about_ca_topic_score_gemma":0.007369019,"domain_scores_codex":[0.999376,0.00003833923,0.0001245287,0.0001412885,0.00007216568,0.0002476746],"domain_scores_gemma":[0.9992776,0.00000725187,0.00007399468,0.0005424168,0.00004071118,0.00005803608],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0000382991,0.0001164423,0.07117488,0.00005091369,0.00007923497,0.00003435388,0.0005324207,0.0008979522,0.9250908,0.0005368823,0.0003746368,0.001073117],"study_design_scores_gemma":[0.001903345,0.000501034,0.9178952,0.00004528017,0.0000413946,0.0002810211,0.0008593227,0.005248053,0.06106064,0.001655874,0.009882623,0.0006262123],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9977937,0.0006788308,0.000452536,0.0002866585,0.0001243548,0.0001056009,0.0001091074,0.000008192048,0.0004409752],"genre_scores_gemma":[0.9958718,0.001026109,0.002209671,0.0002398233,0.00007966242,0.0000173707,0.0002888323,0.00002456749,0.0002421613],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.8640302,"threshold_uncertainty_score":0.5767061,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02458654591811139,"score_gpt":0.2462119206542709,"score_spread":0.2216253747361596,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}