{"id":"W2726739357","doi":"10.1158/1078-0432.ccr-17-0900","title":"Neratinib Efficacy and Circulating Tumor DNA Detection of <i>HER2</i> Mutations in <i>HER2</i> Nonamplified Metastatic Breast Cancer","year":2017,"lang":"en","type":"article","venue":"Clinical Cancer Research","topic":"HER2/EGFR in Cancer Research","field":"Medicine","cited_by":191,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre","funders":"National Cancer Institute; Puma Biotechnology","keywords":"Neratinib; Metastatic breast cancer; Breast cancer; Circulating tumor DNA; Cancer; Medicine; Oncology; Trastuzumab; Cancer research; Internal medicine; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0009214091,0.0003443776,0.0009583539,0.0001313708,0.0001205458,0.0003338662,0.0002598726,0.0002788093,0.001093138],"category_scores_gemma":[0.0009864151,0.000133274,0.000280126,0.0001099881,0.0003125616,0.0002810093,0.0001211864,0.0007843041,0.0001827459],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004509466,"about_ca_system_score_gemma":0.0003373332,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002147186,"about_ca_topic_score_gemma":0.0003998589,"domain_scores_codex":[0.9996749,0.0001366491,0.00003869435,0.00006273836,0.00004901731,0.00003805314],"domain_scores_gemma":[0.9995128,0.0001515652,0.0001594015,0.00003382228,0.000036794,0.0001055327],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.3456404,0.01841904,0.05816362,0.001011657,0.001062885,0.0004367557,0.0002796107,0.004463274,0.3713527,0.0003384826,0.001709941,0.1971216],"study_design_scores_gemma":[0.09888995,0.6104384,0.1311583,0.00006839356,0.001168833,0.002836011,0.0001258465,0.006212597,0.1455332,0.0003656609,0.003140789,0.00006199177],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9989886,0.0004301292,0.0001161944,0.00003941973,0.000007790734,0.00006572791,0.0000484436,0.000008800773,0.0002949679],"genre_scores_gemma":[0.9993501,0.0001178477,0.0001730187,0.00004350508,0.0000162294,0.00004714764,0.0000827751,0.000002728034,0.0001666504],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001093138,"threshold_uncertainty_score":0.004872978,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.3070330761576317,"score_gpt":0.5647289912994085,"score_spread":0.2576959151417768,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}