{"id":"W2726988528","doi":"10.1038/nchem.2800","title":"Synthesis facilitates an understanding of the structural basis for translation inhibition by the lissoclimides","year":2017,"lang":"en","type":"article","venue":"Nature Chemistry","topic":"Microbial Natural Products and Biosynthesis","field":"Medicine","cited_by":46,"is_retracted":false,"has_abstract":false,"ca_institutions":"McGill University","funders":"National Institute of General Medical Sciences; National Cancer Institute; Agence Nationale de la Recherche","keywords":"Chemistry; Semisynthesis; Succinimide; Stereochemistry; Natural product; Structure–activity relationship; Cancer cell lines; Computational biology; Combinatorial chemistry; Biochemistry; Cancer cell; Cancer","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002117753,0.0003949457,0.0002268534,0.0001669988,0.0002919526,0.0004320345,0.000315461,0.0003022472,0.003586287],"category_scores_gemma":[0.0002002281,0.0001521028,0.0002413257,0.0001539167,0.0005401889,0.0005906671,0.0003224193,0.001029146,0.00114211],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007519976,"about_ca_system_score_gemma":0.0006969157,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004546224,"about_ca_topic_score_gemma":0.0007931194,"domain_scores_codex":[0.9999241,0.00001374642,0.000007410129,0.00001696229,0.00001927145,0.00001852201],"domain_scores_gemma":[0.9999094,0.00001990167,0.00002614331,0.00001737088,0.00001328178,0.00001393851],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003713336,0.00008105482,0.0003628674,0.0003473048,0.00001327962,0.0004573929,0.0001268801,0.003280425,0.9232966,0.05265114,0.001221146,0.01779059],"study_design_scores_gemma":[0.00004393969,0.0003727554,0.0003984642,0.00001949178,0.00001447103,0.0003109564,0.00005184471,0.003343924,0.9557207,0.005276375,0.0344307,0.0000163599],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8126182,0.008754571,0.08812648,0.007208363,0.0006126667,0.0001656759,0.001434349,0.00147618,0.07960348],"genre_scores_gemma":[0.9750432,0.003580633,0.01432625,0.0004637792,0.00008321751,0.00006215484,0.0004855678,0.0001168444,0.00583834],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003586287,"threshold_uncertainty_score":0.01199734,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03473205804180195,"score_gpt":0.2839439645011817,"score_spread":0.2492119064593797,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}