{"id":"W2727251202","doi":"10.1002/eji.201646732","title":"Curtailed T‐cell activation curbs effector differentiation and generates CD8<sup>+</sup> T cells with a naturally‐occurring memory stem cell phenotype","year":2017,"lang":"en","type":"article","venue":"European Journal of Immunology","topic":"CAR-T cell therapy research","field":"Medicine","cited_by":27,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute of Infection and Immunity","funders":"Ministero della Salute; Fondazione Italiana per la Ricerca sul Cancro; European Research Council; Fondazione Cariplo; European Commission; Wellcome Trust","keywords":"Biology; Effector; Phenotype; Cytotoxic T cell; Cell biology; Cell; CD8; T cell; Genetics; Gene; Antigen; In vitro; Immune system","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001092767,0.0002993243,0.0002152269,0.0001430186,0.00005895816,0.0002736369,0.0001602141,0.0002340418,0.001684997],"category_scores_gemma":[0.0001068315,0.00008555102,0.0001630875,0.00007933261,0.0001865448,0.0001199463,0.0002092116,0.000512014,0.0004366496],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001207259,"about_ca_system_score_gemma":0.0001400599,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001698264,"about_ca_topic_score_gemma":0.0002764838,"domain_scores_codex":[0.999885,0.00002288978,0.00001572412,0.00002021221,0.00002483987,0.00003136445],"domain_scores_gemma":[0.9998896,0.00002743956,0.00002774814,0.0000187002,0.000008354743,0.0000280787],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005695095,0.00001882763,0.0001093487,0.0000146037,0.000001657317,0.00004033143,0.000008409691,0.00005025937,0.9988639,0.00004382839,0.00002542609,0.0007665624],"study_design_scores_gemma":[0.00001670906,0.000386272,0.001499686,0.000005262545,0.00001025253,0.0003165488,0.00001411946,0.0007012733,0.9950873,0.00003928725,0.001920499,0.000002800135],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9959593,0.0004995917,0.002138927,0.00004781472,0.00001610086,0.00002589104,0.0001735805,0.00008689504,0.001051815],"genre_scores_gemma":[0.9963084,0.0002087021,0.001472329,0.00005546983,0.00001099291,0.00002736899,0.0003008071,0.0000245006,0.001591441],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001684997,"threshold_uncertainty_score":0.005636871,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01550336757659255,"score_gpt":0.2483496289030862,"score_spread":0.2328462613264937,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}