{"id":"W2727317740","doi":"10.1038/cddis.2017.288","title":"KDM2B, an H3K36-specific demethylase, regulates apoptotic response of GBM cells to TRAIL","year":2017,"lang":"en","type":"article","venue":"Cell Death and Disease","topic":"MicroRNA in disease regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":37,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"Weill Cornell Medical College; Koç Üniversitesi Translasyonel Tıp Araştırma Merkezi; Türkiye Bilimsel ve Teknolojik Araştırma Kurumu","keywords":"Demethylase; Gene knockdown; Epigenetics; Apoptosis; Biology; RNA interference; DNA methylation; Cancer research; Cell biology; Programmed cell death; Gene silencing; Downregulation and upregulation; Gene expression; RNA; Gene; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00007044271,0.0002079739,0.0001982876,0.00017682,0.0001418578,0.0001675827,0.00009630194,0.0001484983,0.0007259815],"category_scores_gemma":[0.00006390204,0.0001101758,0.0001449211,0.000132321,0.0001134334,0.00008409606,0.0001634968,0.0001957702,0.0002183492],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002618346,"about_ca_system_score_gemma":0.0001568513,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009825652,"about_ca_topic_score_gemma":0.002113356,"domain_scores_codex":[0.9999425,0.000005435853,0.000004714048,0.0000146454,0.00001718973,0.00001540902],"domain_scores_gemma":[0.9999654,0.000002560604,0.00001457534,0.000003325742,0.00000587349,0.000008341578],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00007294887,0.000007163188,0.0007986863,0.00002472484,0.000003931435,0.00002666818,0.00001072986,0.00005120454,0.9976932,0.00003295723,0.00004179755,0.001236025],"study_design_scores_gemma":[0.00002086112,0.0001531585,0.04100372,0.000007231843,0.00002220396,0.0003019457,0.00005363019,0.001168801,0.9532922,0.00006634747,0.00390403,0.000005897879],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9936302,0.002585318,0.001910267,0.00008518914,0.00001718564,0.00001853069,0.0006225291,0.00008468983,0.00104601],"genre_scores_gemma":[0.9961984,0.0007214474,0.0007616472,0.00005452649,0.000003385267,0.0000162258,0.0006140399,0.000009496324,0.001620835],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009825652,"threshold_uncertainty_score":0.002428651,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01499566013914767,"score_gpt":0.2540152949056784,"score_spread":0.2390196347665307,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}