{"id":"W2727446205","doi":"10.1038/s41598-017-05119-0","title":"C-terminal deletion of NOTCH1 intracellular domain (N1ICD) increases its stability but does not amplify and recapitulate N1ICD-dependent signalling","year":2017,"lang":"en","type":"article","venue":"Scientific Reports","topic":"Developmental Biology and Gene Regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":9,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Sherbrooke","funders":"Fonds de Recherche du Québec - Santé; Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research","keywords":"Terminal (telecommunication); Domain (mathematical analysis); Intracellular; Signalling; Biology; Genetics; Cell biology; Computational biology; Computer science; Mathematics; Telecommunications","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001722747,0.0001548487,0.0001872051,0.00005073686,0.0005559839,0.0001257775,0.0001556741,0.0001954828,0.00003741393],"category_scores_gemma":[0.0002190206,0.000125771,0.00006152508,0.00002954805,0.0004822594,0.0000224803,0.00022325,0.00007634229,0.000002901326],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001742779,"about_ca_system_score_gemma":0.0001046128,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00005075597,"about_ca_topic_score_gemma":0.0001065327,"domain_scores_codex":[0.9982721,0.00008662773,0.0004615943,0.0007289485,0.0002276074,0.0002231035],"domain_scores_gemma":[0.9985222,0.00001349708,0.0005324332,0.0006750248,0.000162212,0.00009461626],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008588236,0.00005608579,0.02831897,0.00004107775,0.00002628319,0.00004869259,0.00005483241,0.00001039417,0.9687505,0.00001685526,0.00002669212,0.0025637],"study_design_scores_gemma":[0.0001681294,0.00005521108,0.02544304,0.00002434867,0.00001816329,0.0001318156,0.0000624437,0.00002548415,0.971347,0.001471468,0.001084495,0.0001684462],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9977916,0.000303376,0.0003425611,0.00006997661,0.0011026,0.0002498975,0.00002122866,0.000009292435,0.0001094241],"genre_scores_gemma":[0.9980814,0.00004733563,0.0007512983,0.00001190034,0.00007650255,0.00001193049,0.0002547152,0.000008972428,0.0007559682],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002875923,"threshold_uncertainty_score":0.5128794,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01414401196197515,"score_gpt":0.2467517934794082,"score_spread":0.2326077815174331,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}