{"id":"W2727622074","doi":"","title":"Lipocalin-2 induces NLRP3 inflammasome activation via HMGB1 induced TLR4 signaling in heart tissue of mice under pressure overload challenge.","year":2017,"lang":"en","type":"article","venue":"PubMed","topic":"Inflammasome and immune disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":46,"is_retracted":false,"has_abstract":true,"ca_institutions":"Ontario Institute for Cancer Research; York University","funders":"","keywords":"Inflammasome; Lipocalin; Autophagy; Pyroptosis; Caspase 1; TLR4; HMGB1; Medicine; Pharmacology; Chemistry; Cell biology; Biology; Internal medicine; Apoptosis; Inflammation; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000321953,0.0006003982,0.0003454321,0.0005451395,0.000175054,0.0003204192,0.0002066024,0.0004856025,0.001793173],"category_scores_gemma":[0.0001491907,0.0002436778,0.0004158373,0.0002296249,0.0004714388,0.0004794697,0.0003332041,0.00132313,0.0003444827],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003116044,"about_ca_system_score_gemma":0.0002387256,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002811524,"about_ca_topic_score_gemma":0.0004880392,"domain_scores_codex":[0.9997886,0.00003964849,0.00002109695,0.00004733488,0.00003665257,0.00006668046],"domain_scores_gemma":[0.9997306,0.00002044871,0.0001033232,0.00002349954,0.00001558437,0.0001064633],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005535999,0.00005834413,0.0002035247,0.00004080375,0.000005642956,0.00007210876,0.0000199932,0.00002065293,0.9985568,0.00005545267,0.00003289136,0.0003801969],"study_design_scores_gemma":[0.0001441217,0.001529042,0.01176333,0.00002057118,0.00003373005,0.00043717,0.0001245615,0.0008216387,0.9837106,0.0002136154,0.001190642,0.00001094354],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9933376,0.001498403,0.003074479,0.0003237956,0.00006897216,0.00004534033,0.0006514699,0.0001352108,0.0008647488],"genre_scores_gemma":[0.9928951,0.0008904723,0.002507898,0.0001731159,0.00002496977,0.0001150709,0.0008684528,0.00004146548,0.00248345],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001793173,"threshold_uncertainty_score":0.00599879,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02079542408203572,"score_gpt":0.2521976247571023,"score_spread":0.2314022006750666,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}