{"id":"W2727622074","doi":"","title":"Lipocalin-2 induces NLRP3 inflammasome activation via HMGB1 induced TLR4 signaling in heart tissue of mice under pressure overload challenge.","year":2017,"lang":"en","type":"article","venue":"PubMed","topic":"Inflammasome and immune disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":46,"is_retracted":false,"has_abstract":true,"ca_institutions":"Ontario Institute for Cancer Research; York University","funders":"","keywords":"Inflammasome; Lipocalin; Autophagy; Pyroptosis; Caspase 1; TLR4; HMGB1; Medicine; Pharmacology; Chemistry; Cell biology; Biology; Internal medicine; Apoptosis; Inflammation; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003408181,0.0001943951,0.0002466814,0.00009099602,0.0001296617,0.0000483765,0.0003628418,0.0003294076,0.00001145146],"category_scores_gemma":[0.0001935981,0.000201467,0.00007553102,0.00006158096,0.00008150357,0.00003892342,0.0001647106,0.0001879449,0.000004381091],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001512124,"about_ca_system_score_gemma":0.00005426332,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002571522,"about_ca_topic_score_gemma":0.00009942838,"domain_scores_codex":[0.998679,0.00007446602,0.0003377461,0.0003495578,0.0001759188,0.000383308],"domain_scores_gemma":[0.9989889,0.00001789083,0.000277791,0.0005585031,0.0000959224,0.00006093736],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001299119,0.00009115534,0.001715472,0.00005034128,0.00008440625,9.262588e-7,0.0001417948,0.000130473,0.9712312,0.00004631373,0.00005673599,0.02632129],"study_design_scores_gemma":[0.0008361675,0.0000768941,0.1441456,0.00002220964,0.00001809225,0.000001258008,0.0001204596,0.00001040083,0.8480501,0.0001508777,0.006349452,0.0002184306],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9963223,0.0006688235,0.0000449229,0.0008370666,0.0001931887,0.0005744189,0.000004650105,0.00001025583,0.001344392],"genre_scores_gemma":[0.9988853,0.0001009325,0.00003831185,0.0001176679,0.0001930316,0.0002604562,0.00004012983,0.0000273588,0.0003367601],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1424302,"threshold_uncertainty_score":0.8215586,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02079542408203572,"score_gpt":0.2521976247571023,"score_spread":0.2314022006750666,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}