{"id":"W2727802742","doi":"10.1016/j.bmcl.2017.07.018","title":"3,5-Bis(3-dimethylaminomethyl-4-hydroxybenzylidene)-4-piperidone and related compounds induce glutathione oxidation and mitochondria-mediated cell death in HCT-116 colon cancer cells","year":2017,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Synthesis and biological activity","field":"Chemistry","cited_by":16,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Saskatchewan","funders":"Canadian Institutes of Health Research; College of Pharmacy and Nutrition, University of Saskatchewan; Saskatchewan Health Research Foundation; University of Saskatchewan","keywords":"Chemistry; Glutathione; Mitochondrion; Mitochondrial permeability transition pore; Cytotoxicity; Reactive oxygen species; Substituent; Cancer cell; Biochemistry; Membrane permeability; Intracellular; Curcumin; Stereochemistry; Programmed cell death; Superoxide; In vitro; Apoptosis; Membrane; Cancer; Enzyme; Biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0003928723,0.0004501419,0.0006245414,0.00005371848,0.0003318112,0.0001230307,0.0004344604,0.0005356348,0.0006640276],"category_scores_gemma":[0.0003971135,0.0003873913,0.00006948231,0.0001322926,0.000497151,0.0001937833,0.0002340038,0.0006973157,0.000009117456],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002441238,"about_ca_system_score_gemma":0.00008295663,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006883494,"about_ca_topic_score_gemma":0.00002394442,"domain_scores_codex":[0.9976525,0.00005858313,0.0005320647,0.0008594663,0.0003718731,0.0005254568],"domain_scores_gemma":[0.9982244,0.0003617119,0.000516025,0.0005554428,0.00004959014,0.0002927705],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001038673,0.0001379632,0.01414041,0.0002279157,0.00004920474,0.00009170547,0.000166406,4.517299e-7,0.9839824,8.043108e-7,0.0002021813,0.0008966274],"study_design_scores_gemma":[0.001790033,0.00002593619,0.03200877,0.0002116762,0.0000862518,0.00004431916,0.0001725651,0.00009179109,0.9646404,0.00001509494,0.0004591201,0.0004540881],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9938922,0.001264839,0.000005373618,0.003202843,0.000189853,0.0001406752,0.00004912739,0.00007209232,0.001182989],"genre_scores_gemma":[0.998219,0.0006683926,0.0001099941,0.0002870008,0.000308212,0.00003361184,0.00006862463,0.00003764141,0.0002675657],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01934211,"threshold_uncertainty_score":0.9998578,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01650214232224577,"score_gpt":0.2379496846176393,"score_spread":0.2214475422953935,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}