{"id":"W2727802742","doi":"10.1016/j.bmcl.2017.07.018","title":"3,5-Bis(3-dimethylaminomethyl-4-hydroxybenzylidene)-4-piperidone and related compounds induce glutathione oxidation and mitochondria-mediated cell death in HCT-116 colon cancer cells","year":2017,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Synthesis and biological activity","field":"Chemistry","cited_by":16,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Saskatchewan","funders":"Canadian Institutes of Health Research; College of Pharmacy and Nutrition, University of Saskatchewan; Saskatchewan Health Research Foundation; University of Saskatchewan","keywords":"Chemistry; Glutathione; Mitochondrion; Mitochondrial permeability transition pore; Cytotoxicity; Reactive oxygen species; Substituent; Cancer cell; Biochemistry; Membrane permeability; Intracellular; Curcumin; Stereochemistry; Programmed cell death; Superoxide; In vitro; Apoptosis; Membrane; Cancer; Enzyme; Biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001319354,0.000311736,0.0002314798,0.000305245,0.0001624013,0.0001241129,0.0001897657,0.0002840918,0.001505447],"category_scores_gemma":[0.00009035834,0.0001674907,0.0002561964,0.0001837688,0.0001567487,0.0001467354,0.0001255721,0.0004627412,0.0003031398],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002130169,"about_ca_system_score_gemma":0.0002478964,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00111444,"about_ca_topic_score_gemma":0.00211407,"domain_scores_codex":[0.9998984,0.00001825013,0.00000960616,0.00001484342,0.00002102499,0.00003782221],"domain_scores_gemma":[0.9999318,0.00001373132,0.00001687755,0.00001022093,0.000008124368,0.00001924126],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005109349,0.00009729858,0.0001134049,0.00006563164,0.000008561708,0.0001010732,0.00002276779,0.0001318727,0.9968656,0.0001151648,0.000109988,0.001857744],"study_design_scores_gemma":[0.00005920028,0.001528382,0.002635294,0.000004235223,0.00001563613,0.0001335426,0.00001745029,0.0004272161,0.9939659,0.00002981206,0.001179236,0.000004102829],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9939949,0.001586691,0.001420158,0.0001291379,0.00006474231,0.00004297006,0.0003569855,0.0001339501,0.002270534],"genre_scores_gemma":[0.9952639,0.0008897691,0.001169779,0.00003890987,0.00001517286,0.00002895353,0.0004586326,0.000008467772,0.002126299],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001505447,"threshold_uncertainty_score":0.005036175,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01650214232224577,"score_gpt":0.2379496846176393,"score_spread":0.2214475422953935,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}