{"id":"W2728001194","doi":"10.1200/po.17.00027","title":"Comprehensive Molecular Characterization of Urachal Adenocarcinoma Reveals Commonalities With Colorectal Cancer, Including a Hypermutable Phenotype","year":2017,"lang":"en","type":"article","venue":"JCO Precision Oncology","topic":"Urinary and Genital Oncology Studies","field":"Medicine","cited_by":49,"is_retracted":false,"has_abstract":true,"ca_institutions":"Smiths Detection (Canada)","funders":"National Cancer Institute","keywords":"MSH6; Microsatellite instability; Adenocarcinoma; MSH2; MLH1; Immune checkpoint; Cancer research; Medicine; Colorectal cancer; Oncology; DNA mismatch repair; Internal medicine; Biology; Cancer; Immunotherapy; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00010678,0.0002074425,0.0002658204,0.0005649815,0.0002198224,0.0002856786,0.0001217467,0.0002092501,0.0006098197],"category_scores_gemma":[0.0002800392,0.0000965595,0.0002093333,0.0003199415,0.0001934982,0.0001208742,0.000210023,0.0002152612,0.0001417487],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001529278,"about_ca_system_score_gemma":0.0001220463,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00052202,"about_ca_topic_score_gemma":0.001440599,"domain_scores_codex":[0.9998568,0.00001567173,0.00001501618,0.0000423152,0.00004303152,0.00002716515],"domain_scores_gemma":[0.9997864,0.00003925238,0.00007095133,0.00002986432,0.00003167682,0.00004185637],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0002495623,0.00002140361,0.05002227,0.00009330941,0.0000435762,0.002111957,0.00008610655,0.0002155827,0.9379532,0.0001068211,0.00006878368,0.009027349],"study_design_scores_gemma":[0.00002237937,0.0007306939,0.7114837,0.00002715647,0.0001360982,0.03029484,0.0005247002,0.002588948,0.2468947,0.0002771907,0.006998741,0.00002090422],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9955305,0.001154398,0.00223712,0.00006152406,0.000005689179,0.0000280882,0.000407805,0.00003536056,0.0005394921],"genre_scores_gemma":[0.996318,0.0004577423,0.002264964,0.00004487973,0.000006028913,0.00001511768,0.0005404893,0.000008555275,0.0003442238],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0006098197,"threshold_uncertainty_score":0.002040029,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06723622734382263,"score_gpt":0.3636070110342152,"score_spread":0.2963707836903926,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}