{"id":"W2728001194","doi":"10.1200/po.17.00027","title":"Comprehensive Molecular Characterization of Urachal Adenocarcinoma Reveals Commonalities With Colorectal Cancer, Including a Hypermutable Phenotype","year":2017,"lang":"en","type":"article","venue":"JCO Precision Oncology","topic":"Urinary and Genital Oncology Studies","field":"Medicine","cited_by":49,"is_retracted":false,"has_abstract":true,"ca_institutions":"Smiths Detection (Canada)","funders":"National Cancer Institute","keywords":"MSH6; Microsatellite instability; Adenocarcinoma; MSH2; MLH1; Immune checkpoint; Cancer research; Medicine; Colorectal cancer; Oncology; DNA mismatch repair; Internal medicine; Biology; Cancer; Immunotherapy; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002018637,0.0002106783,0.0008567664,0.000111194,0.0004521606,0.00001681453,0.0002285681,0.0002197109,0.000126924],"category_scores_gemma":[0.000167236,0.0001664614,0.00008563998,0.0000860377,0.0005497137,0.000193403,0.0003466724,0.0002570586,0.00001680161],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001800907,"about_ca_system_score_gemma":0.0002498144,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001308509,"about_ca_topic_score_gemma":0.0000553746,"domain_scores_codex":[0.9985561,0.000159331,0.0004051404,0.0003346489,0.0002570779,0.0002877356],"domain_scores_gemma":[0.9981822,0.0003078436,0.0005393624,0.0003875192,0.0004779549,0.0001051633],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.008062765,0.0006852532,0.3404208,0.0002133641,0.0005636546,0.000621235,0.001757341,0.00001417868,0.6317092,0.0006378653,0.0003925197,0.01492191],"study_design_scores_gemma":[0.003361528,0.006371097,0.950635,0.0002131925,0.000323142,0.0003690385,0.0003656507,0.00009338223,0.02552488,0.0003922027,0.01214247,0.0002084552],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.989014,0.001114237,0.00008074331,0.002614381,0.0003343443,0.0006005561,0.00006753586,0.00003313245,0.006141057],"genre_scores_gemma":[0.9971702,0.0002369617,0.0008747111,0.0004315945,0.0001533515,0.0001058082,0.00005538803,0.00002410814,0.0009479118],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.6102142,"threshold_uncertainty_score":0.6788099,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06723622734382263,"score_gpt":0.3636070110342152,"score_spread":0.2963707836903926,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}