{"id":"W2728032424","doi":"10.1016/j.radonc.2017.06.007","title":"Phase I dose escalation study of concurrent palliative radiation therapy with sorafenib in three anatomical cohorts (Thorax, Abdomen, Pelvis): The TAP study","year":2017,"lang":"en","type":"article","venue":"Radiotherapy and Oncology","topic":"Management of metastatic bone disease","field":"Medicine","cited_by":9,"is_retracted":false,"has_abstract":false,"ca_institutions":"University Health Network; Princess Margaret Cancer Centre; University of Toronto","funders":"","keywords":"Medicine; Sorafenib; Abdomen; Thorax (insect anatomy); Radiation therapy; Pelvis; Hepatocellular carcinoma; Toxicity; Internal medicine; Oncology; Surgery","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00145522,0.001810916,0.002460203,0.0005188759,0.0003978547,0.001263224,0.0008760243,0.0009794477,0.003843418],"category_scores_gemma":[0.001293651,0.0007751284,0.002238081,0.0005938505,0.001531529,0.001144162,0.0006441456,0.005043267,0.0008448742],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0009482716,"about_ca_system_score_gemma":0.001780537,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001149181,"about_ca_topic_score_gemma":0.002019637,"domain_scores_codex":[0.9995558,0.0001578777,0.00002126679,0.00009983533,0.00005279247,0.0001125527],"domain_scores_gemma":[0.9990507,0.0001355853,0.0001860128,0.0001543285,0.00006167845,0.0004117244],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.7608959,0.1043895,0.006364976,0.0006447888,0.0030269,0.000196965,0.000525873,0.007382081,0.03315096,0.0005502433,0.003630074,0.07924173],"study_design_scores_gemma":[0.5141556,0.4672742,0.0101833,0.0000237525,0.0009672543,0.0002418244,0.0001537537,0.001786875,0.002826385,0.0005108546,0.001827041,0.00004921054],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9961577,0.0004992729,0.0005276892,0.0002208193,0.00009068041,0.001075034,0.0005922486,0.00005665988,0.0007797875],"genre_scores_gemma":[0.9926479,0.0008176811,0.001338625,0.0004259716,0.00009951557,0.001975495,0.001182206,0.00004317599,0.001469435],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003843418,"threshold_uncertainty_score":0.01285756,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04875903053959661,"score_gpt":0.4006526333304575,"score_spread":0.3518936027908609,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}