{"id":"W2728172188","doi":"10.13130/2283-3927/8401","title":"Matrix stiffness and oxigen tension modulate epigenetic conversion of mouse dermal fibroblasts into insulin producing cells.","year":2017,"lang":"en","type":"article","venue":"Riviste UNIMI (Università degli studi di Milano)","topic":"3D Printing in Biomedical Research","field":"Engineering","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Carraresi Foundation","keywords":"Chemistry; Oxygen tension; Stiffness; Insulin; Oxygen; Biophysics; Epigenetics; Matrix (chemical analysis); Extracellular matrix; Materials science; Biochemistry; Biology; Composite material; Chromatography; Organic chemistry","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0002738578,0.0002791903,0.0004044462,0.0003015071,0.0005855763,0.00007115437,0.0006512194,0.000167085,0.0000265761],"category_scores_gemma":[0.0001379286,0.0002952203,0.00007752227,0.000205541,0.0004464682,0.0002699606,0.001004658,0.0003077694,0.00003627929],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001470658,"about_ca_system_score_gemma":0.0000499036,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003452027,"about_ca_topic_score_gemma":0.00004191697,"domain_scores_codex":[0.9982089,0.00006698051,0.0002627222,0.0004811877,0.0004857782,0.0004943899],"domain_scores_gemma":[0.998468,0.0001219139,0.000138603,0.0008139079,0.0001970418,0.0002605516],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0002951591,0.0001764001,0.02207329,0.002902195,0.0004494377,0.0002849232,0.004531228,0.009677004,0.9342808,0.00008833812,0.001098039,0.02414318],"study_design_scores_gemma":[0.004137531,0.0002632181,0.5776665,0.0007933899,0.0001958714,0.00001877299,0.001267427,0.1576678,0.2541044,0.00007749899,0.00268497,0.00112263],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9971277,0.0005137828,0.001073216,0.000138532,0.0002280072,0.0003535571,0.00001734558,0.0001340307,0.0004138848],"genre_scores_gemma":[0.9966041,0.0007260735,0.001596479,0.000006426341,0.0000429241,0.000001908433,0.00001154416,0.00005034485,0.0009601936],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.6801764,"threshold_uncertainty_score":0.99995,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01227725118695794,"score_gpt":0.239854207345756,"score_spread":0.2275769561587981,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}