{"id":"W2728217431","doi":"10.1182/blood.v128.22.665.665","title":"Functional GSTA1 Haplotypes Affect Clearance and Toxicity of Busulfan When Administered in 16 Doses to Pediatric Patients Undergoing Hematopoietic Stem Cell Transplantation: A Multicenter Prospective Study on Behalf of the Pediatric Disease Working Party of the European Society for Blood and Marrow Transplantation (EBMT)","year":2016,"lang":"en","type":"article","venue":"Blood","topic":"Hematopoietic Stem Cell Transplantation","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hospital for Sick Children; Université de Montréal; Alberta Children's Hospital; Centre Hospitalier Universitaire Sainte-Justine","funders":"","keywords":"Medicine; Busulfan; Dosing; Hematopoietic stem cell transplantation; Transplantation; Internal medicine; Therapeutic drug monitoring; Haplotype; Gastroenterology; Tacrolimus; Pharmacology; Oncology; Genotype; Pharmacokinetics; Biology; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003694411,0.0003594451,0.0003408143,0.0002437513,0.0002930726,0.0003494689,0.0001812806,0.0003206967,0.0007289001],"category_scores_gemma":[0.0006623274,0.0002671484,0.0003313156,0.0003688729,0.0002502278,0.0002572101,0.0002049625,0.0005072801,0.0001523308],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001964559,"about_ca_system_score_gemma":0.0001966081,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006144163,"about_ca_topic_score_gemma":0.000543234,"domain_scores_codex":[0.9997464,0.0000726867,0.00002233549,0.00007877337,0.00004338397,0.00003653571],"domain_scores_gemma":[0.999513,0.00007134522,0.0002250826,0.00004010778,0.00003533242,0.0001150147],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.001090628,0.0002473414,0.9941729,0.000007685701,0.00004997837,0.0001595879,0.0001101484,0.00005983287,0.002605006,0.00001260751,0.00004312503,0.001441218],"study_design_scores_gemma":[0.00007043674,0.003381671,0.9939267,0.000003768451,0.00006222734,0.0009748873,0.0001413083,0.0002797024,0.0009144734,0.00001568907,0.0002253281,0.000003701972],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9998628,0.00003179465,0.00002718534,0.000004429454,7.686952e-7,0.000004130036,0.00003863636,8.604956e-7,0.00002942331],"genre_scores_gemma":[0.9997032,0.000030106,0.00006135413,0.00001013163,0.000003175489,0.000007836195,0.0001149132,0.000001320392,0.00006796337],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0007289001,"threshold_uncertainty_score":0.002438426,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.017463602072664,"score_gpt":0.2298552941189541,"score_spread":0.2123916920462901,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}