{"id":"W2728922427","doi":"10.1080/21541248.2017.1337545","title":"Co-dependency between KRAS addiction and ARHGEF2 promotes an adaptive escape from MAPK pathway inhibition","year":2017,"lang":"en","type":"article","venue":"Small GTPases","topic":"Cancer-related Molecular Pathways","field":"Medicine","cited_by":11,"is_retracted":false,"has_abstract":true,"ca_institutions":"St. Michael's Hospital; Princess Margaret Cancer Centre; University of Toronto; University Health Network","funders":"Canadian Institutes of Health Research","keywords":"KRAS; MAPK/ERK pathway; Pancreatic cancer; Biology; Cancer research; Effector; Oncogene; Guanine nucleotide exchange factor; Phosphorylation; Phenotype; Cancer cell; Cell biology; Cancer; Signal transduction; Cell cycle; Genetics; Colorectal cancer; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001259354,0.0002489304,0.0002220606,0.0002286294,0.0001331729,0.0003385552,0.0001626663,0.0002203476,0.001332646],"category_scores_gemma":[0.0001222994,0.0001500394,0.0002311714,0.0001486745,0.0002225899,0.0001555273,0.0003526742,0.0005222296,0.0003476421],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001744789,"about_ca_system_score_gemma":0.0001633432,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000213419,"about_ca_topic_score_gemma":0.0006776626,"domain_scores_codex":[0.999826,0.00003049727,0.00001548261,0.00002442224,0.00004641532,0.00005727407],"domain_scores_gemma":[0.9998767,0.00002409211,0.00002924083,0.00001930208,0.000007597825,0.00004303271],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001394685,0.0000414491,0.0004511045,0.00001005191,0.000004578466,0.0001362867,0.000006026907,0.00003037923,0.9981679,0.0001580718,0.00005072564,0.0008039897],"study_design_scores_gemma":[0.00003461014,0.0004389172,0.01738649,0.000005287045,0.00001975752,0.002542095,0.00004440997,0.001892548,0.9735507,0.0001253069,0.003951347,0.000008655548],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9978144,0.0003089447,0.000725167,0.0000792377,0.00001229272,0.00001023312,0.0001003065,0.0000446242,0.0009047319],"genre_scores_gemma":[0.998129,0.0001660293,0.0005202962,0.00002880283,0.000005094966,0.00001029304,0.000132946,0.00001078158,0.0009967352],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001332646,"threshold_uncertainty_score":0.004458129,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04363008374725846,"score_gpt":0.2792047505976528,"score_spread":0.2355746668503944,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}