{"id":"W2728959095","doi":"10.1073/pnas.1620661114","title":"Social and physical environments early in development predict DNA methylation of inflammatory genes in young adulthood","year":2017,"lang":"en","type":"article","venue":"Proceedings of the National Academy of Sciences","topic":"Birth, Development, and Health","field":"Medicine","cited_by":178,"is_retracted":false,"has_abstract":true,"ca_institutions":"BC Children's Hospital; University of British Columbia; Canadian Institute for Advanced Research","funders":"Office of Extramural Research, National Institutes of Health; National Heart, Lung, and Blood Institute; Fogarty International Center; National Science Foundation","keywords":"Epigenetics; DNA methylation; Inflammation; Gene; Biology; Psychosocial; Methylation; Genetics; Bioinformatics; Immunology; Gene expression; Psychology; Psychiatry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0009420786,0.00006220466,0.000170144,0.0001468699,0.0001584998,0.000008050749,0.0002141558,0.00006567958,0.000001100064],"category_scores_gemma":[0.0001690736,0.0000454298,0.00002024655,0.0001176016,0.0004857714,0.0002917007,0.00009228555,0.0001205723,2.253616e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005681387,"about_ca_system_score_gemma":0.00009431084,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001170225,"about_ca_topic_score_gemma":0.000001306412,"domain_scores_codex":[0.9986783,0.000005104994,0.0003110302,0.0001496767,0.0007472971,0.0001086429],"domain_scores_gemma":[0.9994621,0.00002206208,0.0004344224,0.000006483865,0.00004892982,0.00002604395],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.00003009478,0.00006243517,0.8703973,0.0001338476,0.000007539774,8.101138e-9,0.004076828,0.000001185603,0.113237,0.01086379,0.000005513544,0.001184497],"study_design_scores_gemma":[0.0004358654,0.00002517385,0.8712837,0.0001251359,0.000004007502,8.913049e-7,0.0001934533,0.0001133325,0.1158073,0.01197026,0.000005899788,0.00003498793],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9969814,0.0000344059,1.962175e-7,0.0009685389,0.000007656386,0.0001920511,0.000001612695,0.000001799227,0.001812296],"genre_scores_gemma":[0.9989035,0.0003004261,0.0007044768,0.00002800934,0.00004281267,0.000009108442,1.198724e-7,0.000002367243,0.000009175462],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003883374,"threshold_uncertainty_score":0.1852573,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04811648819078753,"score_gpt":0.3335952120166538,"score_spread":0.2854787238258663,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}