{"id":"W2730033305","doi":"10.1002/ijc.30859","title":"Gene–environment interactions involving functional variants: Results from the Breast Cancer Association Consortium","year":2017,"lang":"en","type":"article","venue":"International Journal of Cancer","topic":"BRCA gene mutations in cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":26,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Royal Victoria Hospital; Université Laval; Centre hospitalier universitaire de Québec","funders":"Universitätsklinikum Hamburg-Eppendorf; Seventh Framework Programme; Instituto de Salud Carlos III; National Health and Medical Research Council; Medical Research Council; Canadian Institutes of Health Research; National Institutes of Health; Deutschen Konsortium für Translationale Krebsforschung; Xunta de Galicia; Rheinische Friedrich-Wilhelms-Universität Bonn; Ministero dello Sviluppo Economico; Institut National Du Cancer; Deutsche Krebshilfe; Deutsche Gesetzliche Unfallversicherung; Nederlandse Organisatie voor Wetenschappelijk Onderzoek; Stichting Tegen Kanker; Agence Nationale de Sécurité Sanitaire de l’Alimentation, de l’Environnement et du Travail; Vetenskapsrådet; Kuopion Yliopistollinen Sairaala; American Cancer Society; Fonds Wetenschappelijk Onderzoek; Ovarian Cancer Research Fund; Bundesministerium für Bildung und Forschung; Cancer Council Victoria; University of Melbourne; Agence Nationale de la Recherche; Robert Bosch Stiftung; European Commission; Eberhard Karls Universität Tübingen; Fondation du cancer du sein du Québec; National Institute for Health and Care Research; Agency for Science, Technology and Research; Ministère du Développement Économique, de l’Innovation et de l’Exportation; Francis Crick Institute; Cancer Care Ontario; Génome Québec; University of Cambridge; Ministerio de Sanidad, Servicios Sociales e Igualdad; Sundhed og Sygdom, Det Frie Forskningsråd; Korea Aerospace University; McGill University Health Centre; Susan G. Komen; David F. and Margaret T. Grohne Family Foundation; National Cancer Institute; Breast Cancer Now; Breast Cancer Research Foundation; McGill University; Ligue Contre le Cancer; VicHealth; Yorkshire Cancer Research; Deutsches Krebsforschungszentrum; Fondation de France; NIHR Biomedical Research Centre, Royal Marsden NHS Foundation Trust/Institute of Cancer Research; U.S. Department of Health and Human Services; Mayo Clinic; Itä-Suomen Yliopisto; Susan G. Komen for the Cure; KWF Kankerbestrijding; Servicio Gallego de Salud; Herlev Hospital; Cancer Research UK","keywords":"Breast cancer; Genetics; Gene; Association (psychology); Biology; Cancer; Oncology; Medicine; Bioinformatics; Computational biology; Psychology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.02282978,0.0008484575,0.0009947309,0.001670674,0.0008467101,0.00138618,0.001036395,0.001202775,0.002466021],"category_scores_gemma":[0.04434315,0.0003607056,0.002342266,0.002991631,0.001002813,0.0006034448,0.001392934,0.001178636,0.0001941648],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003943651,"about_ca_system_score_gemma":0.0007448402,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00971275,"about_ca_topic_score_gemma":0.01107247,"domain_scores_codex":[0.9843201,0.008292865,0.0009657754,0.003505971,0.002303733,0.000611502],"domain_scores_gemma":[0.9297556,0.0559069,0.006072387,0.004896377,0.002344364,0.001024471],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.001991266,0.00004769126,0.9677641,0.0002100057,0.006765269,0.0008360622,0.0005436751,0.001699221,0.003799181,0.0005419464,0.0006897685,0.01511182],"study_design_scores_gemma":[0.00010689,0.0001374136,0.9916251,0.00003534143,0.002580869,0.0006450661,0.000120278,0.001525657,0.0006535609,0.0007703555,0.001757729,0.00004180373],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9790676,0.006205211,0.008799506,0.000865499,0.00006586362,0.00006177434,0.002189262,0.00007041595,0.002674956],"genre_scores_gemma":[0.9956246,0.0006667972,0.001846143,0.0002107234,0.00004919391,0.00005431235,0.001240385,0.00003626757,0.0002717351],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02282978,"threshold_uncertainty_score":0.1207369,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01833269057222601,"score_gpt":0.3028230177511986,"score_spread":0.2844903271789726,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). 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