{"id":"W2730057868","doi":"10.1038/leu.2017.250","title":"SHP2 is required for BCR-ABL1-induced hematologic neoplasia","year":2017,"lang":"en","type":"article","venue":"Leukemia","topic":"Chronic Myeloid Leukemia Treatments","field":"Medicine","cited_by":38,"is_retracted":false,"has_abstract":false,"ca_institutions":"Princess Margaret Cancer Centre; University of Toronto","funders":"National Institute of Arthritis and Musculoskeletal and Skin Diseases; National Cancer Institute","keywords":"Cancer research; Philadelphia chromosome; Tyrosine kinase; ABL; Biology; MAPK/ERK pathway; Myeloid leukemia; breakpoint cluster region; Leukemia; Kinase; Signal transduction; Immunology; Cell biology; Genetics; Chromosomal translocation; Receptor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001792779,0.0002687915,0.0002083896,0.0003155314,0.0004209868,0.0006086679,0.0002981255,0.0003777602,0.006443372],"category_scores_gemma":[0.0002888677,0.0001706821,0.0002436943,0.000178324,0.0002954187,0.0003128716,0.000434412,0.0007519711,0.001001168],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005492064,"about_ca_system_score_gemma":0.0003889055,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007798775,"about_ca_topic_score_gemma":0.001467905,"domain_scores_codex":[0.9997929,0.00001984615,0.00001026178,0.00003830783,0.00007846295,0.00006033706],"domain_scores_gemma":[0.9998821,0.00001667101,0.00003533658,0.0000140127,0.00001439726,0.00003746994],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005575066,0.0001571686,0.002838866,0.00008131234,0.00004292262,0.0005560146,0.00002320336,0.0002642093,0.9833956,0.001086317,0.002146046,0.008850892],"study_design_scores_gemma":[0.000200549,0.0004403031,0.08303601,0.00002438041,0.00007638853,0.00391179,0.000200105,0.003580676,0.8729413,0.0008348858,0.03473337,0.00002032067],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9760685,0.003752492,0.002362025,0.00113457,0.0001937421,0.00006201422,0.001977883,0.0003253657,0.01412347],"genre_scores_gemma":[0.9932222,0.000436622,0.0004719775,0.0001276197,0.00002111198,0.00002430887,0.001522836,0.00002715888,0.004146198],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.006443372,"threshold_uncertainty_score":0.02155524,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05266531239391394,"score_gpt":0.3294850386991547,"score_spread":0.2768197263052408,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}