{"id":"W2730057868","doi":"10.1038/leu.2017.250","title":"SHP2 is required for BCR-ABL1-induced hematologic neoplasia","year":2017,"lang":"en","type":"article","venue":"Leukemia","topic":"Chronic Myeloid Leukemia Treatments","field":"Medicine","cited_by":38,"is_retracted":false,"has_abstract":false,"ca_institutions":"Princess Margaret Cancer Centre; University of Toronto","funders":"National Institute of Arthritis and Musculoskeletal and Skin Diseases; National Cancer Institute","keywords":"Cancer research; Philadelphia chromosome; Tyrosine kinase; ABL; Biology; MAPK/ERK pathway; Myeloid leukemia; breakpoint cluster region; Leukemia; Kinase; Signal transduction; Immunology; Cell biology; Genetics; Chromosomal translocation; Receptor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.000182756,0.0003522649,0.0006695497,0.00008430155,0.0005337311,0.0001000364,0.0004363854,0.0003502643,0.0003692952],"category_scores_gemma":[0.0005690869,0.0002967097,0.0002835253,0.0000658741,0.0001214677,0.0002130333,0.0001449099,0.0002536934,0.0005962386],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.002623261,"about_ca_system_score_gemma":0.001204804,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003627728,"about_ca_topic_score_gemma":0.00004871538,"domain_scores_codex":[0.9979531,0.00002035626,0.0004018193,0.0006439323,0.0003228796,0.0006578855],"domain_scores_gemma":[0.997308,0.000129625,0.0003234563,0.001840683,0.0001194807,0.0002787677],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.004848076,0.00110289,0.1088158,0.003138229,0.003168083,0.00340192,0.004453273,0.00001174947,0.227374,0.009772815,0.4601946,0.1737185],"study_design_scores_gemma":[0.07957001,0.003639384,0.1742631,0.001661144,0.002089752,0.002799334,0.0005325378,0.007976805,0.5402911,0.008587671,0.1762237,0.002365426],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9736609,0.000204138,0.000118152,0.002783105,0.0005869797,0.001245833,0.00003413991,0.0002088195,0.02115793],"genre_scores_gemma":[0.9825256,0.00004101246,0.003187271,0.00137152,0.0004133627,0.00021839,0.00006275061,0.00007037693,0.01210966],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3129171,"threshold_uncertainty_score":0.9999485,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05266531239391394,"score_gpt":0.3294850386991547,"score_spread":0.2768197263052408,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}