{"id":"W2730322226","doi":"10.4049/jimmunol.1602137","title":"Alterations in the Thymic Selection Threshold Skew the Self-Reactivity of the TCR Repertoire in Neonates","year":2017,"lang":"en","type":"article","venue":"The Journal of Immunology","topic":"T-cell and B-cell Immunology","field":"Immunology and Microbiology","cited_by":47,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; University of Alberta; Université de Montréal; Hôpital Maisonneuve-Rosemont","funders":"Canadian Institutes of Health Research","keywords":"T-cell receptor; Biology; Repertoire; Avidity; Negative selection; Immunology; T cell; Immune system; Cell biology; Antigen; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003265821,0.0002665734,0.0004040909,0.0003330723,0.0001007111,0.0003658131,0.0002729823,0.0003133696,0.0008613791],"category_scores_gemma":[0.0008611677,0.0001681601,0.000202004,0.0001330163,0.0002945176,0.0002584311,0.0002918268,0.0005814207,0.0002484889],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002237897,"about_ca_system_score_gemma":0.0001886999,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001729222,"about_ca_topic_score_gemma":0.0002006723,"domain_scores_codex":[0.9996802,0.00005916528,0.00004793005,0.00007956503,0.00007764065,0.00005546785],"domain_scores_gemma":[0.9993266,0.0001484381,0.0002592537,0.00005831488,0.00005270863,0.0001547687],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002381269,0.00001754432,0.006349929,0.00005143332,0.000007101734,0.0004148415,0.00007137779,0.0000677895,0.9898804,0.00008038595,0.00001998649,0.002801025],"study_design_scores_gemma":[0.00001988247,0.001535862,0.267452,0.00005434156,0.00006697187,0.006567787,0.0003951514,0.0007515177,0.7214113,0.0003421214,0.001370413,0.00003268465],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9980305,0.0007298097,0.0007790211,0.00001924935,0.000007621541,0.00000680912,0.00008293094,0.00002579286,0.0003182818],"genre_scores_gemma":[0.9973903,0.0006942202,0.001133118,0.00004920442,0.00001086813,0.00003818174,0.0001525027,0.00002713273,0.000504452],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008613791,"threshold_uncertainty_score":0.002881587,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0129937939628353,"score_gpt":0.239897279612975,"score_spread":0.2269034856501397,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}