{"id":"W2730344022","doi":"10.1038/ng.3911","title":"Ancient selection for derived alleles at a GDF5 enhancer influencing human growth and osteoarthritis risk","year":2017,"lang":"en","type":"article","venue":"Nature Genetics","topic":"Genetics and Physical Performance","field":"Biochemistry, Genetics and Molecular Biology","cited_by":109,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Waterloo","funders":"National Institute of Arthritis and Musculoskeletal and Skin Diseases","keywords":"Enhancer; Biology; Allele; Genetics; Locus (genetics); Phenotype; Haplotype; Gene; Evolutionary biology; Gene expression","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008368338,0.0001634124,0.0001292286,0.00001990371,0.000792047,0.00007751826,0.0001964086,0.0003009134,0.00000354804],"category_scores_gemma":[0.00007765246,0.0001612114,0.00006700544,0.00002254839,0.0001046713,0.000004314285,0.0001898773,0.0001741913,0.000001610275],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001295224,"about_ca_system_score_gemma":0.00002777837,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001317716,"about_ca_topic_score_gemma":0.0003715684,"domain_scores_codex":[0.9990897,0.00001686876,0.0001399189,0.0003782741,0.0001130206,0.0002622137],"domain_scores_gemma":[0.9992683,0.000007253072,0.0001589106,0.0003301777,0.0001448426,0.00009054111],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004586862,0.00001684366,0.02988688,0.00003085465,0.00002480877,2.9987e-7,0.0000502089,0.00004860489,0.9644865,0.00002088927,0.0004655323,0.004922745],"study_design_scores_gemma":[0.0007400962,0.0005467678,0.134952,0.0000133871,0.00003047988,0.000006721044,0.000007056894,0.0002019885,0.8495831,0.0002862265,0.01340969,0.0002225189],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9948593,0.004022965,0.0003354821,0.00004370616,0.0001660052,0.0002614607,0.00004974852,0.000007559576,0.0002538172],"genre_scores_gemma":[0.9954425,0.001274341,0.002358668,0.0001743615,0.0005053496,0.00003787622,0.00005571089,0.0000250512,0.000126138],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1149034,"threshold_uncertainty_score":0.6574012,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005643424439315035,"score_gpt":0.2574544383472391,"score_spread":0.251811013907924,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}