{"id":"W2730344022","doi":"10.1038/ng.3911","title":"Ancient selection for derived alleles at a GDF5 enhancer influencing human growth and osteoarthritis risk","year":2017,"lang":"en","type":"article","venue":"Nature Genetics","topic":"Genetics and Physical Performance","field":"Biochemistry, Genetics and Molecular Biology","cited_by":109,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Waterloo","funders":"National Institute of Arthritis and Musculoskeletal and Skin Diseases","keywords":"Enhancer; Biology; Allele; Genetics; Locus (genetics); Phenotype; Haplotype; Gene; Evolutionary biology; Gene expression","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004663621,0.0003743837,0.0003625666,0.0007345637,0.0003239571,0.0003103926,0.0006070868,0.000491233,0.003925996],"category_scores_gemma":[0.000606342,0.0002577979,0.0003286416,0.0004380379,0.0005799513,0.0001498438,0.000672095,0.0006936415,0.0002246279],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002603073,"about_ca_system_score_gemma":0.0002304738,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008512338,"about_ca_topic_score_gemma":0.001762907,"domain_scores_codex":[0.9996452,0.00008085211,0.00002731715,0.0001011741,0.0000849249,0.00006048553],"domain_scores_gemma":[0.9996684,0.0001110481,0.00005065318,0.00005598931,0.00002650618,0.00008749331],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.001295833,0.0001684466,0.05910914,0.00008588587,0.0002919425,0.003035801,0.0003077456,0.0006880722,0.9120612,0.00357853,0.0001788747,0.0191986],"study_design_scores_gemma":[0.00044189,0.0008492277,0.8649626,0.00009777157,0.000724297,0.01608849,0.0005043503,0.004932063,0.1024805,0.003349542,0.005463268,0.0001060341],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9972567,0.0001831982,0.001411549,0.00007498496,0.00001394034,0.000008558273,0.0001186345,0.0000229999,0.0009095377],"genre_scores_gemma":[0.9980322,0.0000958117,0.0008683071,0.00007089807,0.00001243089,0.000003932391,0.0001118884,0.00002259737,0.0007820759],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003925996,"threshold_uncertainty_score":0.01313382,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005643424439315035,"score_gpt":0.2574544383472391,"score_spread":0.251811013907924,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}