{"id":"W2730375672","doi":"10.1186/s13058-017-0868-8","title":"Two distinct mTORC2-dependent pathways converge on Rac1 to drive breast cancer metastasis","year":2017,"lang":"en","type":"article","venue":"Breast Cancer Research","topic":"PI3K/AKT/mTOR signaling in cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":76,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"National Center for Advancing Translational Sciences; Susan G. Komen for the Cure; Georgia Clinical and Translational Science Alliance; Congressionally Directed Medical Research Programs; Vanderbilt University Medical Center; National Cancer Institute; National Institutes of Health; Vanderbilt-Ingram Cancer Center; Vanderbilt University","keywords":"mTORC2; Cancer research; PI3K/AKT/mTOR pathway; RAC1; Metastasis; Protein kinase B; Guanine nucleotide exchange factor; Biology; Cell migration; Signal transduction; Cancer; Cell biology; mTORC1; Cell","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002278507,0.0006023162,0.0002897164,0.0003875777,0.0002737934,0.0005206294,0.0002865802,0.0004245012,0.001300714],"category_scores_gemma":[0.0001533995,0.0002307389,0.0003741919,0.0001432007,0.0002755719,0.0003460498,0.0004019505,0.0007266465,0.000473515],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004515875,"about_ca_system_score_gemma":0.0003350392,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002864939,"about_ca_topic_score_gemma":0.0007557372,"domain_scores_codex":[0.9997572,0.00003573294,0.00001807041,0.00005181312,0.00008323526,0.00005396855],"domain_scores_gemma":[0.9998622,0.00001505161,0.00003602961,0.00001641167,0.00003095945,0.0000392884],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001258992,0.00003017442,0.000349227,0.00007997724,0.0000122444,0.00006188584,0.00001938198,0.000123876,0.9949535,0.001026606,0.0002012588,0.003016021],"study_design_scores_gemma":[0.00005126067,0.0003119945,0.01126938,0.00003596513,0.00005722076,0.0008274197,0.00004911174,0.004226139,0.9712162,0.0003417337,0.01159684,0.00001675267],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9714742,0.007035479,0.01123348,0.0006557603,0.0000984081,0.00009600534,0.0006037248,0.0002780928,0.008524776],"genre_scores_gemma":[0.9877853,0.002488946,0.005440622,0.0001509252,0.00003044565,0.0001158577,0.0004565452,0.00004193529,0.003489238],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001300714,"threshold_uncertainty_score":0.004351377,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06665687951071642,"score_gpt":0.4058870596212326,"score_spread":0.3392301801105161,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}