{"id":"W2730564452","doi":"10.1038/ncomms16056","title":"The E3 ubiquitin ligase and RNA-binding protein ZNF598 orchestrates ribosome quality control of premature polyadenylated mRNAs","year":2017,"lang":"en","type":"article","venue":"Nature Communications","topic":"RNA Research and Splicing","field":"Biochemistry, Genetics and Molecular Biology","cited_by":236,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"Fonds de Recherche du Québec - Santé; McGill University; National Cancer Institute; National Institutes of Health; Eusko Jaurlaritza; National Institute of General Medical Sciences; Deutscher Akademischer Austauschdienst; Canadian Institutes of Health Research; Leona M. and Harry B. Helmsley Charitable Trust","keywords":"Polyadenylation; Ribosome; Ubiquitin ligase; Biology; RNA; Ubiquitin; Messenger RNA; Ribosomal protein; Ribosomal RNA; RNA-binding protein; Cell biology; Molecular biology; Biochemistry; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001005256,0.0002034638,0.0002029492,0.0001499177,0.0002145082,0.0003618257,0.0001530845,0.0002228783,0.0006053699],"category_scores_gemma":[0.00009368335,0.0001085293,0.0001805191,0.00009647805,0.0001885105,0.0001789897,0.0002885597,0.0001689014,0.000449456],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004510917,"about_ca_system_score_gemma":0.0001467754,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004569383,"about_ca_topic_score_gemma":0.0007009957,"domain_scores_codex":[0.999838,0.0000138378,0.000007949579,0.0000586326,0.0000368177,0.00004464852],"domain_scores_gemma":[0.9999392,0.000003876896,0.00002020401,0.000005152684,0.00001106485,0.00002057686],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00007530292,0.000008714727,0.0009487462,0.00001193413,0.000003330684,0.00009228913,0.000008089622,0.00008481349,0.9969866,0.0002080833,0.00006601591,0.001506122],"study_design_scores_gemma":[0.00002108142,0.00008360332,0.03305154,0.00000642741,0.00001414311,0.0004647626,0.00005575995,0.009065066,0.9529608,0.0003698608,0.003899512,0.000007492835],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9884344,0.001523206,0.007726641,0.00008084825,0.00003331249,0.00001726783,0.000231471,0.0001525036,0.001800209],"genre_scores_gemma":[0.9966827,0.0001954475,0.001361643,0.00002067717,0.000006765712,0.000006536294,0.0001425437,0.00001227873,0.001571382],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0006053699,"threshold_uncertainty_score":0.003272891,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02603560586682781,"score_gpt":0.3546001460122106,"score_spread":0.3285645401453828,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}