{"id":"W2730564452","doi":"10.1038/ncomms16056","title":"The E3 ubiquitin ligase and RNA-binding protein ZNF598 orchestrates ribosome quality control of premature polyadenylated mRNAs","year":2017,"lang":"en","type":"article","venue":"Nature Communications","topic":"RNA Research and Splicing","field":"Biochemistry, Genetics and Molecular Biology","cited_by":236,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"Fonds de Recherche du Québec - Santé; McGill University; National Cancer Institute; National Institutes of Health; Eusko Jaurlaritza; National Institute of General Medical Sciences; Deutscher Akademischer Austauschdienst; Canadian Institutes of Health Research; Leona M. and Harry B. Helmsley Charitable Trust","keywords":"Polyadenylation; Ribosome; Ubiquitin ligase; Biology; RNA; Ubiquitin; Messenger RNA; Ribosomal protein; Ribosomal RNA; RNA-binding protein; Cell biology; Molecular biology; Biochemistry; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000737309,0.0001137443,0.0001468004,0.00002503296,0.001155656,0.000155578,0.001344402,0.0003209105,0.000001540426],"category_scores_gemma":[0.001781715,0.00008254646,0.00006446218,0.0000479866,0.0004685445,0.00001198283,0.0004623852,0.0006865569,0.000001315219],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001055503,"about_ca_system_score_gemma":0.0000944722,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00007232983,"about_ca_topic_score_gemma":0.0005101977,"domain_scores_codex":[0.9989808,0.0002491502,0.0002301742,0.000175085,0.0001471622,0.0002176501],"domain_scores_gemma":[0.9970973,0.0001533505,0.000259634,0.002193021,0.0002091626,0.00008759299],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00007038037,0.00003428384,0.001872595,0.00001790208,0.00006367564,4.792128e-7,0.0000273976,4.931023e-7,0.9913716,0.005068626,0.0002022253,0.001270374],"study_design_scores_gemma":[0.001205347,0.0001455755,0.03854371,0.0001285319,0.0000284948,0.00000991994,0.000267324,0.0002949867,0.9488139,0.0004559163,0.009876136,0.0002301269],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.981023,0.009491402,0.00002454487,0.007909145,0.00002518522,0.0004290639,0.0000676871,0.00001000705,0.001019945],"genre_scores_gemma":[0.9971808,0.001058755,0.0004350446,0.00005172622,0.00003850203,0.00005199509,0.00006320651,0.00001242305,0.001107505],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.04255763,"threshold_uncertainty_score":0.888849,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02603560586682781,"score_gpt":0.3546001460122106,"score_spread":0.3285645401453828,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}