{"id":"W2730666287","doi":"10.1038/nature22993","title":"Tracing the origins of relapse in acute myeloid leukaemia to stem cells","year":2017,"lang":"en","type":"article","venue":"Nature","topic":"Acute Myeloid Leukemia Research","field":"Medicine","cited_by":582,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Toronto; Ontario Institute for Cancer Research; Occupational Cancer Research Centre; Princess Margaret Cancer Centre; University Health Network","funders":"","keywords":"Stem cell; Haematopoiesis; Myeloid; Progenitor cell; Medicine; Cancer research; Chemotherapy; Immunology; Biology; Oncology; Internal medicine; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["research_integrity"],"consensus_categories":[],"category_scores_codex":[0.000578074,0.0001505573,0.0003310105,0.0001538228,0.0001611218,0.00004102259,0.0006682827,0.0008332398,0.00004031785],"category_scores_gemma":[0.000182872,0.00009515181,0.00009427896,0.0002338066,0.0001052944,0.0001182181,0.0001967108,0.00388118,0.0000855108],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006986705,"about_ca_system_score_gemma":0.0003709696,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002244056,"about_ca_topic_score_gemma":0.0001330174,"domain_scores_codex":[0.998553,0.00004902701,0.0002369476,0.0002877469,0.0005112272,0.000362021],"domain_scores_gemma":[0.9982913,0.0001238828,0.0001148094,0.001178306,0.0001436102,0.0001481092],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.002907142,0.0002999335,0.03914764,0.0005765064,0.000526173,0.002164574,0.007255583,0.0001150492,0.7201686,0.006726131,0.1370206,0.0830921],"study_design_scores_gemma":[0.00504947,0.0004530668,0.1213847,0.0007464812,0.0001780566,0.0001685366,0.0008322524,0.0004822648,0.7080057,0.000147919,0.1621792,0.0003722795],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9818046,0.0003768439,0.00001645211,0.01129921,0.0003051117,0.0006120634,0.00002429761,0.00002373128,0.005537694],"genre_scores_gemma":[0.9919264,0.00009407461,0.0005811684,0.001238163,0.0002022169,0.00001729903,0.000003564297,0.00002897908,0.005908129],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.08271983,"threshold_uncertainty_score":0.9984169,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01777219974143713,"score_gpt":0.3241447359647333,"score_spread":0.3063725362232961,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}