{"id":"W2730669434","doi":"10.1155/2017/5804147","title":"IGF-1 Gene Transfer to Human Synovial MSCs Promotes Their Chondrogenic Differentiation Potential without Induction of the Hypertrophic Phenotype","year":2017,"lang":"en","type":"article","venue":"Stem Cells International","topic":"Osteoarthritis Treatment and Mechanisms","field":"Medicine","cited_by":23,"is_retracted":false,"has_abstract":true,"ca_institutions":"Alberta Bone and Joint Health Institute; University of Calgary","funders":"New Energy and Industrial Technology Development Organization; Japan Society for the Promotion of Science; Alberta Innovates; Alberta Innovates - Health Solutions","keywords":"Chondrogenesis; Mesenchymal stem cell; Hyaline cartilage; Chondrocyte; Cell biology; Cartilage; Phenotype; Glycosaminoglycan; Cellular differentiation; Synovial fluid; Gene expression; Biology; Chemistry; Immunology; Pathology; Gene; Medicine; Anatomy; Osteoarthritis; Genetics; Articular cartilage","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00007161537,0.0001492424,0.0001941846,0.00007513867,0.0002373273,0.00005113679,0.0002647907,0.00008728528,0.00016431],"category_scores_gemma":[0.000007562571,0.0001018895,0.0001632211,0.00003305371,0.00005731201,0.0001115164,0.00006724217,0.0001140416,0.00002630811],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00007286826,"about_ca_system_score_gemma":0.00004907196,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002649135,"about_ca_topic_score_gemma":0.00005075794,"domain_scores_codex":[0.9989847,0.00002919949,0.0002401357,0.0002364663,0.0003666896,0.000142795],"domain_scores_gemma":[0.9993174,0.000005837646,0.00008256755,0.0003746265,0.0001562031,0.00006333302],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001633906,0.0001833514,0.002604856,0.00001597252,0.0001181736,0.00000381027,0.0002586287,0.000005436051,0.9889415,0.0005073695,0.00001658598,0.00718092],"study_design_scores_gemma":[0.002274768,0.0005309767,0.01537696,0.0001110255,0.0001301965,0.00003193757,0.00004020514,0.0000822839,0.9809532,0.0002189541,0.0001446593,0.0001047977],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9954842,0.00003600661,0.0003383115,0.0005251343,0.002309193,0.0005963951,0.00005657694,0.00002509489,0.0006290334],"genre_scores_gemma":[0.997318,0.00000732632,0.0001033935,0.00004562694,0.0005337143,0.00002975369,0.00004360594,0.00002376831,0.001894769],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0127721,"threshold_uncertainty_score":0.4154935,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02010722015270847,"score_gpt":0.2498620588789022,"score_spread":0.2297548387261938,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}