{"id":"W2730669434","doi":"10.1155/2017/5804147","title":"IGF-1 Gene Transfer to Human Synovial MSCs Promotes Their Chondrogenic Differentiation Potential without Induction of the Hypertrophic Phenotype","year":2017,"lang":"en","type":"article","venue":"Stem Cells International","topic":"Osteoarthritis Treatment and Mechanisms","field":"Medicine","cited_by":23,"is_retracted":false,"has_abstract":true,"ca_institutions":"Alberta Bone and Joint Health Institute; University of Calgary","funders":"New Energy and Industrial Technology Development Organization; Japan Society for the Promotion of Science; Alberta Innovates; Alberta Innovates - Health Solutions","keywords":"Chondrogenesis; Mesenchymal stem cell; Hyaline cartilage; Chondrocyte; Cell biology; Cartilage; Phenotype; Glycosaminoglycan; Cellular differentiation; Synovial fluid; Gene expression; Biology; Chemistry; Immunology; Pathology; Gene; Medicine; Anatomy; Osteoarthritis; Genetics; Articular cartilage","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001538488,0.0003556986,0.0002152973,0.0002721749,0.0001173913,0.0002630055,0.00008503188,0.0001369083,0.001826012],"category_scores_gemma":[0.0001032199,0.00007786034,0.000205046,0.000143574,0.0002190142,0.0001405397,0.0001651637,0.000350823,0.0004289937],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001871585,"about_ca_system_score_gemma":0.0002488232,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008785889,"about_ca_topic_score_gemma":0.001354036,"domain_scores_codex":[0.9999075,0.00001113914,0.000008053225,0.00001728841,0.00003338065,0.00002255939],"domain_scores_gemma":[0.9999326,0.00001593217,0.00001678674,0.00000734268,0.00001070489,0.00001655027],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004554298,0.00002327146,0.0002038127,0.0000373991,0.000002303824,0.00003252037,0.00002045987,0.0000340247,0.9957271,0.00007229112,0.00003007241,0.003771292],"study_design_scores_gemma":[0.00001903796,0.0003863207,0.002228775,0.000008804772,0.00001501501,0.0001383603,0.00003386418,0.0003982734,0.9938944,0.00003441262,0.002839035,0.000003618451],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9856948,0.002600941,0.00766607,0.000130771,0.0001249812,0.00006519332,0.0002738853,0.0001366962,0.003306505],"genre_scores_gemma":[0.9909669,0.001069783,0.0046297,0.00004080571,0.00002936404,0.00002628737,0.0002730563,0.000027654,0.002936378],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001826012,"threshold_uncertainty_score":0.006108642,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02010722015270847,"score_gpt":0.2498620588789022,"score_spread":0.2297548387261938,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}