{"id":"W2730709380","doi":"10.1016/j.cell.2017.06.025","title":"Development of a Novel Lead that Targets M. tuberculosis Polyketide Synthase 13","year":2017,"lang":"en","type":"article","venue":"Cell","topic":"Microbial Natural Products and Biosynthesis","field":"Medicine","cited_by":182,"is_retracted":false,"has_abstract":true,"ca_institutions":"Discovery Centre","funders":"Argonne National Laboratory; Medical Research Council; National Institutes of Health; National Institute of Allergy and Infectious Diseases; Bill and Melinda Gates Foundation; Universität Zürich; Wellcome Trust; Welch Foundation","keywords":"Polyketide synthase; Biology; Mycobacterium tuberculosis; Tuberculosis; Rifampicin; In vivo; Microbiology; Polyketide; Isoniazid; Drug resistance; Drug; Pharmacology; Antibiotics; Enzyme; Biochemistry; Biosynthesis; Medicine; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001921652,0.0004743871,0.000485083,0.0003137866,0.0002426288,0.0003955908,0.0004598288,0.0004962336,0.003332311],"category_scores_gemma":[0.0001406931,0.0001574435,0.0003049021,0.0001890012,0.0002497499,0.0002631671,0.0004079206,0.0007536673,0.000993679],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003178589,"about_ca_system_score_gemma":0.0006012511,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004361076,"about_ca_topic_score_gemma":0.001044395,"domain_scores_codex":[0.9999099,0.00001261611,0.000005728327,0.00001716669,0.00002765009,0.00002691636],"domain_scores_gemma":[0.9999382,0.00000570404,0.000009638957,0.00000513833,0.00001613382,0.00002516462],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000979225,0.0007710473,0.0008199217,0.0006308521,0.00004964066,0.001123112,0.0001308326,0.003749379,0.9117109,0.004081198,0.003619857,0.07233405],"study_design_scores_gemma":[0.001895666,0.01330213,0.002074728,0.0001807386,0.0001150724,0.001993791,0.0001196587,0.009421413,0.9007998,0.001526576,0.0685129,0.00005749294],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8568792,0.02240927,0.0690736,0.003140412,0.001475464,0.00162676,0.002195398,0.001274019,0.0419259],"genre_scores_gemma":[0.9317662,0.009928904,0.03324114,0.001075074,0.00009095135,0.0003947169,0.001876467,0.00008434438,0.02154214],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003332311,"threshold_uncertainty_score":0.01114774,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03490636498253565,"score_gpt":0.2633097208632057,"score_spread":0.2284033558806701,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}