{"id":"W2730709380","doi":"10.1016/j.cell.2017.06.025","title":"Development of a Novel Lead that Targets M. tuberculosis Polyketide Synthase 13","year":2017,"lang":"en","type":"article","venue":"Cell","topic":"Microbial Natural Products and Biosynthesis","field":"Medicine","cited_by":182,"is_retracted":false,"has_abstract":true,"ca_institutions":"Discovery Centre","funders":"Argonne National Laboratory; Medical Research Council; National Institutes of Health; National Institute of Allergy and Infectious Diseases; Bill and Melinda Gates Foundation; Universität Zürich; Wellcome Trust; Welch Foundation","keywords":"Polyketide synthase; Biology; Mycobacterium tuberculosis; Tuberculosis; Rifampicin; In vivo; Microbiology; Polyketide; Isoniazid; Drug resistance; Drug; Pharmacology; Antibiotics; Enzyme; Biochemistry; Biosynthesis; Medicine; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001771242,0.0001377721,0.0002708133,0.00005279408,0.0001847565,0.00002325742,0.000183698,0.00008457144,0.0002382461],"category_scores_gemma":[0.0001523063,0.00009952001,0.00008473569,0.00003021167,0.00008914595,0.00006688869,0.0001007791,0.0001141999,0.00006608841],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000033861,"about_ca_system_score_gemma":0.00008672497,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00009376329,"about_ca_topic_score_gemma":0.00003245789,"domain_scores_codex":[0.9991671,0.000006709956,0.0002006113,0.0002487288,0.0001653569,0.0002115049],"domain_scores_gemma":[0.9991351,0.00002147075,0.0001598692,0.0005215799,0.00007009807,0.00009189272],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00007690984,0.0002813467,0.000589069,0.0002017704,0.00003857739,0.000009236699,0.0002309544,1.044422e-7,0.9840786,0.000003898904,0.002847054,0.01164246],"study_design_scores_gemma":[0.0006267913,0.00002737997,0.01065604,0.0001448739,0.00005969714,0.00000902121,0.00005746399,0.0000161188,0.9581873,0.000001715897,0.03008868,0.0001249444],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.98953,0.0007323756,0.00005058127,0.002019892,0.0002254631,0.0002287463,0.00001648153,0.00002198938,0.007174427],"genre_scores_gemma":[0.984252,0.00007369935,0.01180029,0.0001910114,0.0001079335,9.174896e-7,0.00000952743,0.00001602101,0.003548609],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02724163,"threshold_uncertainty_score":0.4058308,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03490636498253565,"score_gpt":0.2633097208632057,"score_spread":0.2284033558806701,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}