{"id":"W2731206995","doi":"10.1038/s41598-017-04874-4","title":"HDAC6: A Novel Histone Deacetylase Implicated in Pulmonary Arterial Hypertension","year":2017,"lang":"en","type":"article","venue":"Scientific Reports","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":102,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université Laval; Institut universitaire de cardiologie et de pneumologie de Québec","funders":"National Heart, Lung, and Blood Institute; Canadian Institutes of Health Research; Institut universitaire de cardiologie et de pneumologie de Québec, Université Laval; National Institutes of Health; Canada Research Chairs","keywords":"HDAC6; Cancer research; Apoptosis; Hypoxia (environmental); Histone deacetylase; Myofibroblast; Medicine; Chemistry; Pharmacology; Cell biology; Histone; Biology; Pathology; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001581896,0.0006579094,0.0004678395,0.0003667762,0.0003230183,0.0005625064,0.0003550534,0.0005202519,0.001945832],"category_scores_gemma":[0.00009538735,0.00016028,0.0005072724,0.0004483164,0.0002958344,0.0003241434,0.0002637033,0.000663524,0.001143004],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004624036,"about_ca_system_score_gemma":0.0002935035,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005115801,"about_ca_topic_score_gemma":0.0009117211,"domain_scores_codex":[0.9998988,0.00001027385,0.000009465725,0.00002757539,0.00003058967,0.00002331941],"domain_scores_gemma":[0.9999471,0.000003309647,0.00001643608,0.000004929229,0.000009793981,0.00001846695],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0011381,0.0001638417,0.004547806,0.001037416,0.00013383,0.0007875091,0.00005313327,0.0003753649,0.9130612,0.001221296,0.002835044,0.07464549],"study_design_scores_gemma":[0.0002658159,0.001336623,0.02859795,0.00009488737,0.0003642303,0.008881849,0.00008951736,0.0016926,0.801212,0.0008596721,0.1565599,0.00004501186],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"review","genre_gemma":"empirical","genre_scores_codex":[0.4646268,0.4788394,0.02608019,0.002652276,0.001899462,0.0003018992,0.004351572,0.001157475,0.02009078],"genre_scores_gemma":[0.8651612,0.105941,0.009673136,0.0004940663,0.0005728783,0.00006963083,0.005111694,0.00006022611,0.01291619],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.001945832,"threshold_uncertainty_score":0.006509423,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02516819168591976,"score_gpt":0.304581651206014,"score_spread":0.2794134595200943,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}