{"id":"W2731206995","doi":"10.1038/s41598-017-04874-4","title":"HDAC6: A Novel Histone Deacetylase Implicated in Pulmonary Arterial Hypertension","year":2017,"lang":"en","type":"article","venue":"Scientific Reports","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":102,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université Laval; Institut universitaire de cardiologie et de pneumologie de Québec","funders":"National Heart, Lung, and Blood Institute; Canadian Institutes of Health Research; Institut universitaire de cardiologie et de pneumologie de Québec, Université Laval; National Institutes of Health; Canada Research Chairs","keywords":"HDAC6; Cancer research; Apoptosis; Hypoxia (environmental); Histone deacetylase; Myofibroblast; Medicine; Chemistry; Pharmacology; Cell biology; Histone; Biology; Pathology; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001100276,0.0001877717,0.0002162022,0.0001604566,0.0006687773,0.0002689889,0.0003842532,0.0001950558,0.00003797524],"category_scores_gemma":[0.0006440929,0.0001841858,0.0001129881,0.0001300412,0.0005974894,0.00001912894,0.0004021368,0.0001617174,0.00004716101],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00008070679,"about_ca_system_score_gemma":0.0003018179,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002464861,"about_ca_topic_score_gemma":0.0002215427,"domain_scores_codex":[0.9974244,0.00004022754,0.0004644468,0.001154279,0.0004269575,0.0004896419],"domain_scores_gemma":[0.996874,0.000006299727,0.000291201,0.002427657,0.0002084881,0.0001923045],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00007254136,0.000242299,0.0005597133,0.00001015686,0.000006937968,0.0008650374,0.00002238734,0.00000877603,0.9818957,0.00000389425,0.01503314,0.00127937],"study_design_scores_gemma":[0.0004968235,0.00005196976,0.007569102,0.00003370316,0.000006510141,0.001390895,0.00001647247,0.000174043,0.9029426,0.0001148767,0.08692474,0.0002782924],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9934005,0.0001600456,0.00007674935,0.0002859646,0.00354722,0.0003453284,0.000008449221,0.00002017638,0.002155568],"genre_scores_gemma":[0.9935564,0.000007631058,0.0002485553,0.00002929905,0.0002504171,0.00004811779,0.000231949,0.0000305547,0.005597047],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.07895317,"threshold_uncertainty_score":0.7510879,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02516819168591976,"score_gpt":0.304581651206014,"score_spread":0.2794134595200943,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}