{"id":"W2731268259","doi":"10.1021/acs.biomac.7b00590","title":"Nontransformed and Cancer Cells Can Utilize Different Endocytic Pathways To Internalize Dendritic Nanoparticle Variants: Implications on Nanocarrier Design","year":2017,"lang":"en","type":"article","venue":"Biomacromolecules","topic":"Dendrimers and Hyperbranched Polymers","field":"Materials Science","cited_by":22,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia; BC Cancer Agency","funders":"BC Cancer Agency; Canadian Institutes of Health Research; Natural Sciences and Engineering Research Council of Canada; University of British Columbia; Michael Smith Health Research BC","keywords":"Pinocytosis; Endocytosis; Endocytic cycle; Nanocarriers; Internalization; Polyethylene glycol; Clathrin; Chemistry; Biophysics; Cell biology; Nanoparticle; Cancer cell; PEG ratio; Nanotechnology; Cell; Biochemistry; Materials science; Biology; Cancer","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001197949,0.0002534095,0.0002742891,0.00006721163,0.0005846946,0.0004336722,0.0005080522,0.00006623665,0.0003449104],"category_scores_gemma":[0.00004646097,0.0002096955,0.00006621889,0.00005076675,0.000217058,0.0001177077,0.0001067494,0.0000584863,0.0001035727],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00008325073,"about_ca_system_score_gemma":0.00008730472,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000861851,"about_ca_topic_score_gemma":0.0003881073,"domain_scores_codex":[0.9984334,0.00007711575,0.0002586787,0.0004960923,0.0002023156,0.0005324657],"domain_scores_gemma":[0.9988052,0.00006653778,0.0001026966,0.0006238504,0.0000458145,0.0003558658],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00007562251,0.00006959725,0.0001913458,0.00001835714,0.00002439547,0.00003471376,0.0008581602,0.000003000156,0.9936246,0.001043773,0.0001586339,0.003897774],"study_design_scores_gemma":[0.0007393751,0.0001623623,0.00867181,0.00009315114,0.00005830085,0.00002202375,0.00006880249,0.00005517342,0.989161,0.0003029615,0.0003908371,0.0002742274],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9950336,0.0004233321,0.00177854,0.0009389085,0.0006261872,0.0004422565,0.0003285131,0.00005919159,0.0003694644],"genre_scores_gemma":[0.9985251,0.00006919351,0.0004924179,0.0005001999,0.0000562515,0.0001866378,0.00000250447,0.00003378788,0.0001339023],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.008480465,"threshold_uncertainty_score":0.8551134,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0385865195781417,"score_gpt":0.2839862835326309,"score_spread":0.2453997639544893,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}