{"id":"W2731378980","doi":"10.1016/j.mrgentox.2017.06.004","title":"Genome-wide bisulfite sensitivity profiling of yeast suggests bisulfite inhibits transcription","year":2017,"lang":"en","type":"article","venue":"Mutation Research/Genetic Toxicology and Environmental Mutagenesis","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"Terry Fox Research Institute; BC Cancer Agency","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research; Michael Smith Health Research BC","keywords":"Bisulfite; Sodium bisulfite; Bisulfite sequencing; Biology; Mutant; DNA methylation; DNA; RNA; Transcription (linguistics); Molecular biology; Genetics; Gene; Chemistry; Gene expression","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0009289573,0.0001966948,0.0002179912,0.0001614102,0.0006327224,0.00005737223,0.0001698635,0.0002845647,0.00003732847],"category_scores_gemma":[0.000229646,0.0002097966,0.00007934236,0.0000649435,0.0007683567,0.00001822723,0.000203191,0.000150005,0.00001354838],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003961941,"about_ca_system_score_gemma":0.00005137031,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00004968408,"about_ca_topic_score_gemma":0.0001206228,"domain_scores_codex":[0.9979646,0.0004356948,0.0003443568,0.0005531509,0.000319578,0.0003826284],"domain_scores_gemma":[0.9990247,0.00006661098,0.0001980742,0.0005016321,0.00005160634,0.000157333],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001189862,0.0001140261,0.09147003,0.00003581874,0.0000443927,0.00001667768,0.000168325,0.0006352023,0.8962003,0.000007775315,0.000003143476,0.01118533],"study_design_scores_gemma":[0.0003921221,0.0002867525,0.489892,0.000007668616,0.00001672525,0.000008690884,0.0001346544,0.0002020673,0.5086394,0.00008313898,0.0002220696,0.0001147465],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9950997,0.001621823,0.002268559,0.000147254,0.0001009742,0.0004750022,0.0001098305,0.00000781225,0.0001690892],"genre_scores_gemma":[0.996226,0.001807368,0.001281708,0.00003328478,0.0000944432,0.00004909375,0.0002291435,0.00003329577,0.0002456658],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.398422,"threshold_uncertainty_score":0.8555257,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02835400949184669,"score_gpt":0.3003853482797094,"score_spread":0.2720313387878627,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}