{"id":"W2731383842","doi":"10.3390/ma10070731","title":"Improved Gene Transfer with Functionalized Hollow Mesoporous Silica Nanoparticles of Reduced Cytotoxicity","year":2017,"lang":"en","type":"article","venue":"Materials","topic":"RNA Interference and Gene Delivery","field":"Biochemistry, Genetics and Molecular Biology","cited_by":20,"is_retracted":false,"has_abstract":true,"ca_institutions":"Memorial University of Newfoundland","funders":"Pearl River S and T Nova Program of Guangzhou; Guangdong Provincial Key Laboratory of Construction Foundation; Higher Education Discipline Innovation Project; National Natural Science Foundation of China","keywords":"Mesoporous silica; Biocompatibility; Gene delivery; Materials science; Transfection; Nanoparticle; Cytotoxicity; Viability assay; Biophysics; Chemical engineering; Nanotechnology; Mesoporous material; Chemistry; Organic chemistry; Cell; In vitro; Biochemistry; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001669653,0.0003723644,0.0002786623,0.000212419,0.00008134972,0.0001829661,0.0001997684,0.0005270123,0.0005221554],"category_scores_gemma":[0.0001930793,0.0001494343,0.0003391018,0.0001475714,0.0001947142,0.0003068981,0.0001769036,0.000286795,0.0002986037],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004119286,"about_ca_system_score_gemma":0.0002058896,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004999921,"about_ca_topic_score_gemma":0.000618911,"domain_scores_codex":[0.9998908,0.00001023221,0.00001166344,0.00002910836,0.0000379591,0.0000201982],"domain_scores_gemma":[0.9999082,0.00001830757,0.0000271118,0.000007766253,0.00002603339,0.00001267664],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00001263481,0.000004336672,0.00002285866,0.00002248666,0.000002125696,0.00001968998,0.000004989823,0.0001016584,0.9988894,0.00005153087,0.00001666156,0.0008515964],"study_design_scores_gemma":[0.000005898333,0.00007667318,0.0004192675,0.000002431465,0.000006871023,0.00006915591,0.000003979253,0.001437777,0.996787,0.00003793767,0.001147759,0.000005211003],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9654602,0.002994389,0.02793817,0.0001669151,0.00008388799,0.00006496397,0.0002118874,0.0004853479,0.002594218],"genre_scores_gemma":[0.9777392,0.001239384,0.01648385,0.00009837314,0.00002311778,0.00005606785,0.0003567074,0.0000582452,0.003945189],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0005270123,"threshold_uncertainty_score":0.002988756,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01479746240894742,"score_gpt":0.2438484459043938,"score_spread":0.2290509834954464,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}