{"id":"W2731383842","doi":"10.3390/ma10070731","title":"Improved Gene Transfer with Functionalized Hollow Mesoporous Silica Nanoparticles of Reduced Cytotoxicity","year":2017,"lang":"en","type":"article","venue":"Materials","topic":"RNA Interference and Gene Delivery","field":"Biochemistry, Genetics and Molecular Biology","cited_by":20,"is_retracted":false,"has_abstract":true,"ca_institutions":"Memorial University of Newfoundland","funders":"Pearl River S and T Nova Program of Guangzhou; Guangdong Provincial Key Laboratory of Construction Foundation; Higher Education Discipline Innovation Project; National Natural Science Foundation of China","keywords":"Mesoporous silica; Biocompatibility; Gene delivery; Materials science; Transfection; Nanoparticle; Cytotoxicity; Viability assay; Biophysics; Chemical engineering; Nanotechnology; Mesoporous material; Chemistry; Organic chemistry; Cell; In vitro; Biochemistry; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001409344,0.0001260533,0.0002068462,0.00001496698,0.0001144299,0.00005507407,0.0002212024,0.00009238145,0.0002083348],"category_scores_gemma":[0.00003317535,0.00009748668,0.0000523495,0.00001217962,0.0001194273,0.000007424042,0.00005000949,0.00002030037,0.000006842142],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000005066636,"about_ca_system_score_gemma":0.00004740752,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001288231,"about_ca_topic_score_gemma":0.00003230223,"domain_scores_codex":[0.9992611,0.00003927417,0.0002092776,0.0002439577,0.00008534164,0.0001610749],"domain_scores_gemma":[0.9992666,0.000003243374,0.00009103432,0.0005036333,0.00009093293,0.0000445703],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001043244,0.00005034344,0.0002008398,0.00001374164,0.00007695825,0.000002463754,0.00002549611,0.000002291647,0.9982256,0.00001092652,0.000108057,0.0002400312],"study_design_scores_gemma":[0.0008392139,0.0004937718,0.006381566,0.00001270041,0.00002825674,0.00001080478,0.00001202573,0.000001815137,0.9917637,0.0000201781,0.0003058003,0.0001301368],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9991016,0.0000665172,0.000138206,0.00009650734,0.0001516774,0.0001721747,0.00009410579,0.000008499703,0.0001706794],"genre_scores_gemma":[0.9988529,0.00004067367,0.0002123232,0.00009337232,0.0001343969,0.00003439709,0.00005595199,0.00001551788,0.0005604857],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.006461876,"threshold_uncertainty_score":0.3975391,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01479746240894742,"score_gpt":0.2438484459043938,"score_spread":0.2290509834954464,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}