{"id":"W2731426244","doi":"10.1158/1535-7163.mct-16-0666","title":"Inactivation of the Kinase Domain of CDK10 Prevents Tumor Growth in a Preclinical Model of Colorectal Cancer, and Is Accompanied by Downregulation of Bcl-2","year":2017,"lang":"en","type":"article","venue":"Molecular Cancer Therapeutics","topic":"Genetic factors in colorectal cancer","field":"Medicine","cited_by":23,"is_retracted":false,"has_abstract":true,"ca_institutions":"Canada's Michael Smith Genome Sciences Centre; University of British Columbia; BC Cancer Agency","funders":"Canadian Institutes of Health Research","keywords":"Downregulation and upregulation; Colorectal cancer; Cancer research; Cancer; Kinase; Protein kinase domain; Medicine; Chemistry; Biology; Cell biology; Internal medicine; Gene; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002413379,0.0005751054,0.0003116719,0.0005081037,0.0002028612,0.0002066903,0.0003641135,0.0003372307,0.00348372],"category_scores_gemma":[0.0001435339,0.0002000901,0.0002418465,0.000181039,0.0003827975,0.0002292921,0.0001238895,0.001171516,0.0005216179],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005535513,"about_ca_system_score_gemma":0.0004275108,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001302285,"about_ca_topic_score_gemma":0.002524822,"domain_scores_codex":[0.9998362,0.0000300073,0.00001160466,0.00002817371,0.00004320334,0.00005086705],"domain_scores_gemma":[0.9998029,0.00003831727,0.00003978063,0.00002709174,0.00001394663,0.00007794019],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001201824,0.0008736631,0.0002394685,0.00007331416,0.00001403921,0.00008389646,0.00001483487,0.000218343,0.9933447,0.0003386675,0.0004953718,0.003101886],"study_design_scores_gemma":[0.0001500362,0.002531432,0.001658499,0.000008100365,0.00001474925,0.0002079432,0.00001846822,0.001982172,0.9909924,0.00007025538,0.002361529,0.000004483882],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9885502,0.001678115,0.003173563,0.000534075,0.000227125,0.0001179267,0.0009955914,0.0004305344,0.004292921],"genre_scores_gemma":[0.9878219,0.0007706296,0.002230327,0.00007656968,0.00001946112,0.0001377898,0.0008689428,0.00005163172,0.008022778],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00348372,"threshold_uncertainty_score":0.0116542,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04300192920630522,"score_gpt":0.3410777621829696,"score_spread":0.2980758329766644,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}