{"id":"W2732221342","doi":"10.1126/scitranslmed.aak9969","title":"Genetic and epigenetic inactivation of <i>SESTRIN1</i> controls mTORC1 and response to EZH2 inhibition in follicular lymphoma","year":2017,"lang":"en","type":"article","venue":"Science Translational Medicine","topic":"Cancer-related gene regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":57,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; University of British Columbia; BC Cancer Agency","funders":"National Cancer Institute; NIH Office of the Director; Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung; American Cancer Society","keywords":"EZH2; Epigenetics; Follicular lymphoma; Cancer research; Biology; Lymphoma; Genetics; Medicine; Immunology; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005967714,0.00008922046,0.0001275906,0.0001645569,0.0001467428,0.00001646498,0.00008047845,0.00005555423,0.00000364978],"category_scores_gemma":[0.0002904468,0.00008411868,0.00001366039,0.0001575848,0.0006151569,0.00002083388,0.00002731032,0.0000271002,3.42164e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002631028,"about_ca_system_score_gemma":0.0001711532,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00009861514,"about_ca_topic_score_gemma":0.0001022652,"domain_scores_codex":[0.999019,0.0000402309,0.0002260769,0.0003037991,0.000276706,0.0001341847],"domain_scores_gemma":[0.9994372,0.00003371308,0.0001091446,0.0002210196,0.0001113852,0.00008760222],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0004160483,0.00001265286,0.00841254,0.000008381287,0.000003845204,9.937697e-7,0.0001523571,0.0008038352,0.9746121,0.00009744053,0.000005738121,0.01547411],"study_design_scores_gemma":[0.001977273,0.0003148368,0.8090411,0.00008605172,0.00001064837,0.00001584569,0.00002862842,0.0005256644,0.1870882,0.0003851758,0.0004400999,0.00008644209],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9920515,0.0006881152,0.004483806,0.002308203,0.00006367043,0.0002981358,0.000006318261,0.000002652645,0.00009764294],"genre_scores_gemma":[0.9989019,0.00009708164,0.0007994612,0.00007248978,0.00008236607,0.00001484867,0.000008391427,0.000006018895,0.0000174135],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.8006286,"threshold_uncertainty_score":0.343026,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009501495076256857,"score_gpt":0.2751316113345343,"score_spread":0.2656301162582774,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}