{"id":"W2732249235","doi":"10.1101/159905","title":"Ponatinib shows potent antitumor activity in small cell carcinoma of the ovary hypercalcemic type (SCCOHT) through multi-kinase inhibition","year":2017,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Chromatin Remodeling and Cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":8,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Ottawa; Ontario Institute for Cancer Research; Ottawa Hospital; University of British Columbia","funders":"","keywords":"Ponatinib; Cancer research; Biology; SMARCA4; Ovarian cancer; Kinase; Cancer; Tyrosine kinase; Pharmacology; Dasatinib; Receptor; Epigenetics; Genetics; Chromatin remodeling","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001167417,0.000266919,0.0004369991,0.0002135025,0.0001539116,0.0002709249,0.0002367429,0.0002360395,0.002126256],"category_scores_gemma":[0.0001453763,0.00008932932,0.000307354,0.000263499,0.0001506449,0.0001346874,0.0001484456,0.0005578689,0.0003816037],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000349701,"about_ca_system_score_gemma":0.000294308,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006214032,"about_ca_topic_score_gemma":0.001594494,"domain_scores_codex":[0.9999131,0.000009089487,0.00001083769,0.00001424978,0.00002759167,0.00002515108],"domain_scores_gemma":[0.9999518,0.000009063274,0.00001001539,0.000005892436,0.00001110402,0.00001207533],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0006100165,0.0003251179,0.0008599499,0.0002608591,0.00004824608,0.0002075257,0.00002092322,0.0005938344,0.9820825,0.0001509459,0.0006396779,0.0142004],"study_design_scores_gemma":[0.0004459533,0.003919074,0.00946533,0.00001069945,0.0000919238,0.001899552,0.00004557699,0.001945573,0.9741246,0.0001063164,0.007932487,0.00001287779],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9911191,0.002412702,0.001686668,0.0002329255,0.00004826635,0.0001579399,0.001035707,0.0002052579,0.003101278],"genre_scores_gemma":[0.9950415,0.0009941986,0.001020286,0.00006792559,0.000005713946,0.00005000463,0.001288169,0.00001493454,0.001517217],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002126256,"threshold_uncertainty_score":0.00711298,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02686799362079918,"score_gpt":0.2439251566016003,"score_spread":0.2170571629808011,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}