{"id":"W2732348423","doi":"10.1016/j.joca.2017.07.001","title":"Deletion of 12/15-lipoxygenase accelerates the development of aging-associated and instability-induced osteoarthritis","year":2017,"lang":"en","type":"article","venue":"Osteoarthritis and Cartilage","topic":"Osteoarthritis Treatment and Mechanisms","field":"Medicine","cited_by":37,"is_retracted":false,"has_abstract":false,"ca_institutions":"Cegep de Saint Hyacinthe; Hôpital du Sacré-Cœur de Montréal; Université de Montréal","funders":"Canadian Institutes of Health Research","keywords":"Osteoarthritis; Thrombospondin; Cartilage; Chemistry; Nitric oxide; Pathogenesis; Prostaglandin E2; Inflammation; Matrix metalloproteinase; Arachidonate 5-lipoxygenase; Aggrecanase; Metalloproteinase; Endocrinology; Internal medicine; Arachidonic acid; Medicine; Pathology; Biochemistry; Enzyme; Anatomy","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002805047,0.0005734327,0.0005031409,0.0006793714,0.000197891,0.0004346659,0.0002823812,0.0004493497,0.002803044],"category_scores_gemma":[0.0002149664,0.0004144002,0.0005268837,0.0002366917,0.0004767149,0.0002736862,0.0004269921,0.0007294543,0.0006252725],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002527322,"about_ca_system_score_gemma":0.0004112337,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009616443,"about_ca_topic_score_gemma":0.001454547,"domain_scores_codex":[0.9997224,0.00004154542,0.00004089332,0.00004798623,0.0000650765,0.00008204173],"domain_scores_gemma":[0.9994817,0.00004910815,0.0002290976,0.00003694275,0.00002965117,0.00017341],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000497455,0.0000781524,0.0003850203,0.00002107431,0.00000970848,0.000140598,0.00001402396,0.00005000313,0.9978016,0.0001065819,0.00003171994,0.000864054],"study_design_scores_gemma":[0.0001349678,0.001517236,0.0345259,0.0000214781,0.00009963364,0.001124336,0.0001372475,0.001854349,0.9573145,0.0002164872,0.003026783,0.00002702517],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9966034,0.000813101,0.001677123,0.00006614213,0.00004177957,0.0000182935,0.0002798361,0.00009544652,0.0004048875],"genre_scores_gemma":[0.9947546,0.0005702793,0.000989362,0.0000344725,0.00001301979,0.00001960092,0.000335862,0.00004327505,0.003239631],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002803044,"threshold_uncertainty_score":0.009377182,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02305193254501484,"score_gpt":0.2575283936692691,"score_spread":0.2344764611242542,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}