{"id":"W2732648784","doi":"10.1093/brain/awx133","title":"Inflammasomes in neurological diseases: emerging pathogenic and therapeutic concepts","year":2017,"lang":"en","type":"review","venue":"Brain","topic":"Inflammasome and immune disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":170,"is_retracted":false,"has_abstract":true,"ca_institutions":"Women and Children’s Health Research Institute; University of Alberta","funders":"","keywords":"Inflammasome; Pyroptosis; Caspase 1; Neuroscience; Biology; Caspase; Programmed cell death; Interleukin; Pyrin domain; Inflammation; Immunology; Cytokine; Apoptosis; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0001821605,0.0003397678,0.0007086103,0.00008172238,0.00009962865,0.00005365631,0.0003639631,0.0003666558,0.00001991974],"category_scores_gemma":[0.0002319505,0.0002780936,0.0002887886,0.00005247411,0.0001645881,0.000003612318,0.0002426536,0.0002197383,0.00001371384],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000004854103,"about_ca_system_score_gemma":0.0001407862,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000003384376,"about_ca_topic_score_gemma":0.00001490108,"domain_scores_codex":[0.9984952,0.0002451406,0.0003510772,0.0005043657,0.0000814741,0.0003227501],"domain_scores_gemma":[0.9991316,0.00004566295,0.0002086737,0.0005378659,0.00001586633,0.00006037036],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0000139231,0.00002055105,0.0004348508,0.0007331867,0.00006556181,0.00002914396,0.00002431936,4.16035e-7,0.00009950626,0.00004420684,0.0001889783,0.9983454],"study_design_scores_gemma":[0.0003469961,0.0001038835,0.0009942014,0.0003975863,0.00009215326,0.0000215448,0.0000143781,0.000003166714,0.000003419681,0.00005633638,0.9976394,0.0003269181],"study_design_candidate":"design_other","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.004349401,0.9946761,0.000003364338,0.00009232186,0.0001204461,0.0004275386,0.00002862023,0.00001022459,0.0002920332],"genre_scores_gemma":[0.001557717,0.9970373,0.000007581461,0.0002790981,0.0001495686,0.0001028048,0.0002635712,0.00004138606,0.0005609983],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9980184,"threshold_uncertainty_score":0.9999671,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03362584748556047,"score_gpt":0.3544701313357831,"score_spread":0.3208442838502226,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}