{"id":"W2732809609","doi":"10.1016/j.radonc.2017.06.025","title":"Inhibition of ataxia telangiectasia related-3 (ATR) improves therapeutic index in preclinical models of non-small cell lung cancer (NSCLC) radiotherapy","year":2017,"lang":"en","type":"article","venue":"Radiotherapy and Oncology","topic":"DNA Repair Mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":35,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"Queen's University Belfast; Queen's University; Cancer Research UK","keywords":"Radiation therapy; Medicine; In vivo; Cancer research; Lung cancer; Ataxia-telangiectasia; non-small cell lung cancer (NSCLC); Pathology; Oncology; Internal medicine; DNA damage; A549 cell; Biology; DNA","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003295034,0.0005826309,0.0006789571,0.0006600372,0.000254059,0.0003620899,0.0005987464,0.0004564727,0.00232875],"category_scores_gemma":[0.0001906357,0.0002295605,0.0003717322,0.0003522488,0.0003902116,0.0005013372,0.0001569856,0.001490179,0.0005108081],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004685877,"about_ca_system_score_gemma":0.0004342528,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00110356,"about_ca_topic_score_gemma":0.002113487,"domain_scores_codex":[0.9998201,0.00003168064,0.00001439798,0.00002912612,0.00004875038,0.00005604797],"domain_scores_gemma":[0.9998512,0.00002223715,0.00004564286,0.00002114005,0.00001655094,0.00004313235],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00144531,0.000749403,0.0001561504,0.00008545156,0.00002907121,0.00004308255,0.00001823903,0.0003867835,0.9903731,0.000220069,0.0004736856,0.006019638],"study_design_scores_gemma":[0.000153553,0.005117462,0.001815796,0.00001005191,0.00008624673,0.0001564537,0.00002614757,0.001294765,0.988937,0.0000932989,0.002299853,0.000009217794],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9887502,0.004278212,0.002652064,0.0003916081,0.0001649955,0.00008068849,0.0005390893,0.0005014745,0.002641644],"genre_scores_gemma":[0.9914885,0.002551964,0.001227272,0.00006737122,0.00002276336,0.00005710898,0.0007431894,0.00004583893,0.003796099],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00232875,"threshold_uncertainty_score":0.007790446,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01680832145180231,"score_gpt":0.3154441250879221,"score_spread":0.2986358036361197,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}