{"id":"W2733319564","doi":"10.1371/journal.ppat.1006479","title":"Divergent roles for Ly6C+CCR2+CX3CR1+ inflammatory monocytes during primary or secondary infection of the skin with the intra-phagosomal pathogen Leishmania major","year":2017,"lang":"en","type":"article","venue":"PLoS Pathogens","topic":"Research on Leishmaniasis Studies","field":"Medicine","cited_by":84,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary","funders":"Division of Intramural Research, National Institute of Allergy and Infectious Diseases; National Institute of Allergy and Infectious Diseases; Institute of Infection and Immunity; Coordenação de Aperfeiçoamento de Pessoal de Nível Superior; Canadian Institutes of Health Research; National Institutes of Health","keywords":"Biology; Immunology; Leishmania major; Monocyte; Dendritic cell; CCL2; CCR2; Pathogen; Chemokine; Inflammation; Microbiology; Macrophage; Leishmania; Immune system; Parasite hosting; Chemokine receptor; In vitro","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000308135,0.0002035383,0.0002839004,0.0003040339,0.0002037692,0.0004912789,0.0001674794,0.0003596706,0.001301952],"category_scores_gemma":[0.0002668445,0.0001567209,0.0001783296,0.0001365434,0.0002185661,0.0002691125,0.0002852915,0.00059163,0.0004415102],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001541466,"about_ca_system_score_gemma":0.0002070985,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002810048,"about_ca_topic_score_gemma":0.000508565,"domain_scores_codex":[0.9996251,0.00008791139,0.00004227345,0.00007267753,0.00004797653,0.0001239911],"domain_scores_gemma":[0.9998061,0.00002210356,0.00004056366,0.00002527775,0.0000316837,0.00007432435],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0008409955,0.00004019542,0.002498219,0.00006989137,0.000003473953,0.0002381623,0.0001381634,0.00002678184,0.9925453,0.0002572738,0.00005434105,0.00328724],"study_design_scores_gemma":[0.0002149324,0.003158872,0.216867,0.0001454887,0.0001542184,0.007359362,0.001812642,0.001923962,0.7604108,0.0008555146,0.007046304,0.00005095165],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9955661,0.001616064,0.00124102,0.00007840382,0.00002296714,0.00005916403,0.0002386064,0.00002540174,0.001152329],"genre_scores_gemma":[0.9951997,0.0007462267,0.001897754,0.0001298983,0.00002496729,0.0001019601,0.0002711044,0.00001069331,0.001617834],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001301952,"threshold_uncertainty_score":0.004355431,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0236142644898008,"score_gpt":0.2637466273535314,"score_spread":0.2401323628637306,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}