{"id":"W2733319564","doi":"10.1371/journal.ppat.1006479","title":"Divergent roles for Ly6C+CCR2+CX3CR1+ inflammatory monocytes during primary or secondary infection of the skin with the intra-phagosomal pathogen Leishmania major","year":2017,"lang":"en","type":"article","venue":"PLoS Pathogens","topic":"Research on Leishmaniasis Studies","field":"Medicine","cited_by":84,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary","funders":"Division of Intramural Research, National Institute of Allergy and Infectious Diseases; National Institute of Allergy and Infectious Diseases; Institute of Infection and Immunity; Coordenação de Aperfeiçoamento de Pessoal de Nível Superior; Canadian Institutes of Health Research; National Institutes of Health","keywords":"Biology; Immunology; Leishmania major; Monocyte; Dendritic cell; CCL2; CCR2; Pathogen; Chemokine; Inflammation; Microbiology; Macrophage; Leishmania; Immune system; Parasite hosting; Chemokine receptor; In vitro","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["sts"],"consensus_categories":[],"category_scores_codex":[0.0004760635,0.0003538264,0.0005725913,0.00009977929,0.002294317,0.0001639751,0.0005749539,0.0001304482,0.00006951846],"category_scores_gemma":[0.0006251056,0.0001790405,0.0002851508,0.0001292351,0.0005845031,0.000283845,0.0006561955,0.0004143566,0.00001447259],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002006849,"about_ca_system_score_gemma":0.00038639,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00007754307,"about_ca_topic_score_gemma":0.001151943,"domain_scores_codex":[0.9975997,0.0001512542,0.0004435334,0.0004812993,0.0007439021,0.0005803119],"domain_scores_gemma":[0.997348,0.0002275311,0.0004909785,0.001366019,0.0004209641,0.0001464804],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.002204804,0.0004344688,0.6335335,0.001602684,0.001241473,0.0001191841,0.001804644,0.00001386066,0.3519494,0.00007937561,0.00105178,0.005964878],"study_design_scores_gemma":[0.002449617,0.0004717563,0.8977696,0.0002993291,0.0004237451,0.00007380926,0.0003527765,0.00006238416,0.09624718,0.00003669237,0.001590092,0.0002230711],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9939051,0.0005272471,0.00003409785,0.001577729,0.0001449122,0.002315933,0.0002132001,0.00007267694,0.001209163],"genre_scores_gemma":[0.9966149,0.0004321358,0.0004437349,0.0001487381,0.0005203654,0.0005918724,0.0000187014,0.00008344779,0.001146099],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2642361,"threshold_uncertainty_score":0.9990045,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0236142644898008,"score_gpt":0.2637466273535314,"score_spread":0.2401323628637306,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}