{"id":"W2734100395","doi":"10.1371/journal.pone.0180578","title":"Delivery of gene targeting siRNAs to breast cancer cells using a multifunctional peptide complex that promotes both targeted delivery and endosomal release","year":2017,"lang":"en","type":"article","venue":"PLoS ONE","topic":"RNA Interference and Gene Delivery","field":"Biochemistry, Genetics and Molecular Biology","cited_by":20,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary","funders":"Alberta Innovates - Health Solutions; Cancer Research Society","keywords":"Small interfering RNA; Endosome; Peptide; Gene knockdown; RNA interference; Cell biology; Cell-penetrating peptide; Biology; RNA; Gene silencing; Molecular biology; Chemistry; Biochemistry; Gene; Intracellular","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002989296,0.0003677003,0.000473229,0.0002446864,0.0001594662,0.0004646006,0.0002228711,0.0004195253,0.0006216805],"category_scores_gemma":[0.0001422088,0.0001807757,0.0002950179,0.0002062586,0.0002067477,0.0001794027,0.0002459576,0.0004235402,0.0003323358],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004689338,"about_ca_system_score_gemma":0.0002831884,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005029466,"about_ca_topic_score_gemma":0.0006485472,"domain_scores_codex":[0.9998212,0.00002735784,0.00002181348,0.00004597223,0.0000548302,0.00002883601],"domain_scores_gemma":[0.999907,0.00001736693,0.000024921,0.00001201097,0.00001762917,0.00002103203],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0000244831,0.00001258962,0.00002648525,0.00002296146,0.000004410382,0.00001848545,0.000007023141,0.00009134714,0.9989655,0.00005598842,0.00001751281,0.0007531857],"study_design_scores_gemma":[0.00002627279,0.0002271171,0.0005048019,0.000003001679,0.00001687455,0.00014421,0.000005352959,0.00120728,0.9955433,0.00001776069,0.002299294,0.000004792439],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9793729,0.002048353,0.01605867,0.0001397541,0.00005123905,0.0001609667,0.0002411225,0.0001591906,0.001767859],"genre_scores_gemma":[0.9746845,0.001145964,0.0205093,0.0001314706,0.00001971279,0.000136531,0.0004979362,0.00003855229,0.002836047],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0006216805,"threshold_uncertainty_score":0.003402412,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05418360446413158,"score_gpt":0.2519483050479834,"score_spread":0.1977647005838518,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}