{"id":"W2734173772","doi":"10.1002/cbic.201700184","title":"Two Completely Different Mechanisms for Highly Specific Na<sup>+</sup> Recognition by DNAzymes","year":2017,"lang":"en","type":"article","venue":"ChemBioChem","topic":"Advanced biosensing and bioanalysis techniques","field":"Biochemistry, Genetics and Molecular Biology","cited_by":26,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Waterloo","funders":"Natural Sciences and Engineering Research Council of Canada; China Scholarship Council","keywords":"Deoxyribozyme; Computational biology; Chemistry; Nanotechnology; DNA; Physics; Biology; Biochemistry; Materials science","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.000148944,0.0003193275,0.0003095021,0.00003806693,0.0004796208,0.0001386445,0.0004206438,0.000224731,0.000007365214],"category_scores_gemma":[0.0000922692,0.0002846493,0.0002619036,0.00003264896,0.0001776531,0.000009167637,0.0001667303,0.0001039905,0.000008968347],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003199264,"about_ca_system_score_gemma":0.0000167102,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000009921889,"about_ca_topic_score_gemma":0.000004991517,"domain_scores_codex":[0.998505,0.00002352028,0.0002751247,0.0006639918,0.0001566306,0.0003757307],"domain_scores_gemma":[0.9985759,0.0000174852,0.0002530096,0.0008648744,0.0001704742,0.0001183062],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00009936898,0.00009681572,0.00002866105,0.00001971268,0.00007328864,0.000001156184,0.000009431984,3.659401e-7,0.9755524,0.0001134838,0.01217878,0.01182654],"study_design_scores_gemma":[0.0008534633,0.0002248323,0.00003467696,0.00003228666,0.00005069616,0.000008000147,0.00005567452,0.0001301445,0.9774035,0.001848469,0.01894801,0.0004102249],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9688196,0.0004027931,0.02831792,0.0004956106,0.0001102143,0.0004058112,0.0003741121,0.0001023844,0.0009715441],"genre_scores_gemma":[0.9830454,0.0002482094,0.01295492,0.0002511202,0.0003548674,0.0000574768,0.001902482,0.00004717537,0.001138335],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.015363,"threshold_uncertainty_score":0.9999605,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.027689708046443,"score_gpt":0.2816645043936784,"score_spread":0.2539747963472354,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}