{"id":"W2734339327","doi":"10.1111/irv.12466","title":"Lineage‐specific epitope profiles for <scp>HPAI</scp> H5 pre‐pandemic vaccine selection and evaluation","year":2017,"lang":"en","type":"article","venue":"Influenza and Other Respiratory Viruses","topic":"vaccines and immunoinformatics approaches","field":"Biochemistry, Genetics and Molecular Biology","cited_by":8,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hospital for Sick Children; Mount Sinai Hospital; University of Toronto; Public Health Ontario","funders":"National Institute of Allergy and Infectious Diseases; National Institutes of Health","keywords":"Epitope; Phylogenetic tree; Biology; Virology; Lineage (genetic); Clade; Influenza A virus subtype H5N1; Hemagglutinin (influenza); Epitope mapping; Phylogenetics; Computational biology; Genetics; Gene; Antigen; Virus","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00058893,0.0001945567,0.0001755697,0.00005387367,0.0004296339,0.0002056549,0.0001633858,0.0001804266,0.000006522209],"category_scores_gemma":[0.0002970286,0.0001666431,0.00005228596,0.0000270086,0.00005027994,0.00003967243,0.00009285786,0.00007814816,0.000003458096],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001129507,"about_ca_system_score_gemma":0.00005260753,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001791711,"about_ca_topic_score_gemma":0.00004233186,"domain_scores_codex":[0.9990303,0.00004685295,0.0003086189,0.0002939321,0.0001112458,0.0002090356],"domain_scores_gemma":[0.9991311,0.00003327709,0.0002743753,0.0003649909,0.0001312051,0.00006503946],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001679906,0.00004786821,0.7192837,0.0001167239,0.0001221109,1.531796e-7,0.000325188,0.00006269624,0.2568386,0.0001135281,0.002440043,0.02048137],"study_design_scores_gemma":[0.00191072,0.0004335324,0.0719678,0.0000295169,0.00004847009,0.000005702168,0.0001105503,0.0005976618,0.09887542,0.00007220554,0.8258206,0.000127814],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9902322,0.008422372,0.0002969348,0.000003453758,0.00008631867,0.0006814342,0.00002793667,0.00002044538,0.0002289146],"genre_scores_gemma":[0.9880076,0.0001613464,0.0009472209,0.009479334,0.0008749899,0.0003714986,0.000008270617,0.0000820482,0.0000676956],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.8233806,"threshold_uncertainty_score":0.6795508,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1184024825756833,"score_gpt":0.3668921413802986,"score_spread":0.2484896588046153,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}