{"id":"W2734344008","doi":"10.1101/143933","title":"The Multiple Sclerosis Genomic Map: Role of peripheral immune cells and resident microglia in susceptibility","year":2017,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"T-cell and B-cell Immunology","field":"Immunology and Microbiology","cited_by":116,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University and Génome Québec Innovation Centre","funders":"National Institute of Environmental Health Sciences; National Institute of Neurological Disorders and Stroke; National Institutes of Health; H. Lundbeck A/S; National Multiple Sclerosis Society; Vlaamse regering; Norges Forskningsråd; Vetenskapsrådet; Knut och Alice Wallenbergs Stiftelse; KU Leuven; Fonds Wetenschappelijk Onderzoek; AFA Försäkring; Lundbeckfonden; Institut National de la Santé et de la Recherche Médicale; Medical Research Council; Strategiske Forskningsråd; European Commission; Fondation pour l'Aide à la Recherche sur la Sclérose en Plaques; King's College London; Bundesministerium für Bildung und Forschung; National Institute for Health and Care Research; Multiple Sclerosis Society; National Institute of Allergy and Infectious Diseases; Agence Nationale de la Recherche; Wellcome Trust; Biogen; Harvard NeuroDiscovery Center; Forskningsrådet om Hälsa, Arbetsliv och Välfärd; Scleroseforeningen","keywords":"Multiple sclerosis; Microglia; Immune system; Major histocompatibility complex; Biology; Gene; Immunology; Innate immune system; Genetics; Neuroscience; Inflammation","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003351226,0.0003002761,0.00034731,0.001241563,0.0003349664,0.0004305331,0.0002055399,0.0002166378,0.003557783],"category_scores_gemma":[0.0009763006,0.0001107135,0.0003498736,0.001101065,0.000146769,0.000110254,0.0003222223,0.000285623,0.0007122359],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000172252,"about_ca_system_score_gemma":0.0004375838,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002472653,"about_ca_topic_score_gemma":0.00291105,"domain_scores_codex":[0.9997662,0.00004515797,0.0000166195,0.00009265602,0.00005278082,0.0000266349],"domain_scores_gemma":[0.9996228,0.000148463,0.00005616821,0.00004925364,0.00006801827,0.00005531317],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.002803359,0.0001465111,0.37041,0.001404035,0.0009219374,0.004231487,0.00156341,0.005907339,0.3547253,0.003753782,0.01385287,0.24028],"study_design_scores_gemma":[0.0001055111,0.0002759322,0.9396588,0.000100967,0.0004685121,0.002231279,0.0002609645,0.003210249,0.02180885,0.003668988,0.02817423,0.00003578623],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9701203,0.001502733,0.01033776,0.0005149044,0.00004623087,0.0000437164,0.015233,0.0002964986,0.001904783],"genre_scores_gemma":[0.9681737,0.0006018413,0.0119672,0.0001129548,0.00009516047,0.00004391337,0.01712096,0.00006698914,0.001817294],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003557783,"threshold_uncertainty_score":0.01190192,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01315784844592634,"score_gpt":0.1990137396456765,"score_spread":0.1858558911997501,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}