{"id":"W2734434515","doi":"10.1161/circulationaha.117.028208","title":"Long-Term Efficacy and Safety of the Microsomal Triglyceride Transfer Protein Inhibitor Lomitapide in Patients With Homozygous Familial Hypercholesterolemia","year":2017,"lang":"en","type":"letter","venue":"Circulation","topic":"Lipoproteins and Cardiovascular Health","field":"Medicine","cited_by":137,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Robarts Research Institute; University of Cape Town; Cedars-Sinai Medical Center; University of Pennsylvania","keywords":"Medicine; Microsomal triglyceride transfer protein; Familial hypercholesterolemia; Triglyceride; Internal medicine; Cholesterylester transfer protein; Endocrinology; Cholesterol; Lipoprotein; Very low-density lipoprotein","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007447954,0.0002466083,0.001033734,0.0001799412,0.0005711978,0.0007369653,0.0004116391,0.002670518,0.001445515],"category_scores_gemma":[0.002817189,0.0001023266,0.0004810338,0.0003142117,0.000434492,0.0003829003,0.0001492163,0.002262108,0.0007898961],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001360643,"about_ca_system_score_gemma":0.0006302035,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000558531,"about_ca_topic_score_gemma":0.001507105,"domain_scores_codex":[0.9995837,0.0001594744,0.00004511882,0.00004562029,0.00009081455,0.00007531277],"domain_scores_gemma":[0.9986616,0.0006332638,0.0001839475,0.00005361404,0.0001600948,0.0003073877],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"observational","study_design_scores_codex":[0.0713463,0.005462119,0.1716274,0.0009319514,0.0008150103,0.07425351,0.0009063541,0.001833369,0.03120764,0.004324151,0.1477704,0.4895219],"study_design_scores_gemma":[0.05023202,0.07147126,0.4902951,0.001762349,0.002644509,0.1161579,0.001714675,0.01387282,0.01538861,0.01927624,0.2168027,0.0003818955],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.7866936,0.03169565,0.0006010906,0.1528327,0.002401381,0.0001124917,0.0005143418,0.00009079656,0.02505783],"genre_scores_gemma":[0.941699,0.005335797,0.0003614429,0.04395851,0.00508581,0.00007565248,0.0003874461,0.00001243722,0.003083908],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002670518,"threshold_uncertainty_score":0.009872198,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01058963419053549,"score_gpt":0.2247302837732149,"score_spread":0.2141406495826794,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}