{"id":"W2734434515","doi":"10.1161/circulationaha.117.028208","title":"Long-Term Efficacy and Safety of the Microsomal Triglyceride Transfer Protein Inhibitor Lomitapide in Patients With Homozygous Familial Hypercholesterolemia","year":2017,"lang":"en","type":"letter","venue":"Circulation","topic":"Lipoproteins and Cardiovascular Health","field":"Medicine","cited_by":137,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Robarts Research Institute; University of Cape Town; Cedars-Sinai Medical Center; University of Pennsylvania","keywords":"Medicine; Microsomal triglyceride transfer protein; Familial hypercholesterolemia; Triglyceride; Internal medicine; Cholesterylester transfer protein; Endocrinology; Cholesterol; Lipoprotein; Very low-density lipoprotein","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002761634,0.0003280832,0.0007605677,0.0001308575,0.0001388885,0.00003658988,0.0001611,0.0006294702,0.000005908886],"category_scores_gemma":[0.0000565115,0.0002229219,0.0002330525,0.0001034662,0.0002059325,0.000114501,0.00003953703,0.0009665972,0.000001965218],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002151567,"about_ca_system_score_gemma":0.0002564763,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001464213,"about_ca_topic_score_gemma":0.00004940555,"domain_scores_codex":[0.9977424,0.0001870359,0.0005347223,0.00050324,0.0007083965,0.0003242605],"domain_scores_gemma":[0.9985352,0.00002479996,0.000190971,0.001037535,0.000143993,0.00006754191],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.002598256,0.0002654887,0.9514111,0.003019965,0.0003448833,0.0002232793,0.000413394,0.00001751773,0.002905109,0.000001754974,0.0006024264,0.03819678],"study_design_scores_gemma":[0.0117161,0.0001790438,0.9835731,0.00201928,0.0002587163,0.00005680512,0.00000226373,0.000003050842,0.0005292829,0.000003239258,0.001430289,0.0002288016],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9875919,0.0002090431,0.00007164015,0.007438728,0.0001734659,0.004385513,0.00005825036,0.00001827735,0.0000532335],"genre_scores_gemma":[0.9931853,0.00001309491,0.00002948369,0.005143956,0.001127966,0.00007186734,0.0003014873,0.00007126489,0.00005552055],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03796798,"threshold_uncertainty_score":0.9090489,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01058963419053549,"score_gpt":0.2247302837732149,"score_spread":0.2141406495826794,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}