{"id":"W2734507137","doi":"10.1038/s41598-017-05325-w","title":"NEK1 kinase domain structure and its dynamic protein interactome after exposure to Cisplatin","year":2017,"lang":"en","type":"article","venue":"Scientific Reports","topic":"DNA Repair Mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":40,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Centro Nacional de Pesquisa em Energia e Materiais; Ministero dello Sviluppo Economico; Fundação de Amparo à Pesquisa do Estado de São Paulo; Conselho Nacional de Desenvolvimento Científico e Tecnológico; Ontario Ministry of Economic Development and Innovation; Genome Canada; Wellcome Trust; GlaxoSmithKline; Pfizer; Eli Lilly and Company","keywords":"Biology; DNA damage; Cell biology; Kinase; Ciliogenesis; Interactome; Cilium; G2-M DNA damage checkpoint; DNA repair; CHEK1; Protein kinase domain; Proteostasis; DNA; Genetics; Cancer; Cell cycle checkpoint; Cell cycle; Mutant; Gene","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00005964001,0.0001600231,0.0001854286,0.0001478331,0.0001853864,0.0001626388,0.0002579496,0.0001947875,0.001561696],"category_scores_gemma":[0.0001437903,0.0001048202,0.0001460985,0.000147498,0.0001369864,0.0001704443,0.0001384142,0.0003964366,0.0003284014],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004841409,"about_ca_system_score_gemma":0.0001258796,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008439453,"about_ca_topic_score_gemma":0.0009586338,"domain_scores_codex":[0.9999281,0.000006637832,0.00000406493,0.00002325799,0.00002056258,0.00001729272],"domain_scores_gemma":[0.9999354,0.00001201992,0.00001612278,0.00000589339,0.00000796181,0.00002262889],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004218756,0.00003356111,0.000773529,0.0000465066,0.00001602094,0.0001685363,0.00002757491,0.0003211086,0.9967405,0.0001419536,0.0001549991,0.001153662],"study_design_scores_gemma":[0.00003948236,0.0001563144,0.05355602,0.00001149418,0.00003009862,0.001510558,0.00007060624,0.005891077,0.9332842,0.0001650506,0.005266582,0.00001838641],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9967191,0.0008373327,0.0009396024,0.0001092191,0.00001626038,0.000007302391,0.0004366995,0.00001516286,0.0009193902],"genre_scores_gemma":[0.9955809,0.0004505276,0.0007147565,0.00005238532,0.000003881119,0.00002004315,0.001223407,0.000009300559,0.001944732],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001561696,"threshold_uncertainty_score":0.005224407,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.004777589282881584,"score_gpt":0.2439179622818265,"score_spread":0.2391403729989449,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}