{"id":"W2734507137","doi":"10.1038/s41598-017-05325-w","title":"NEK1 kinase domain structure and its dynamic protein interactome after exposure to Cisplatin","year":2017,"lang":"en","type":"article","venue":"Scientific Reports","topic":"DNA Repair Mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":40,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Centro Nacional de Pesquisa em Energia e Materiais; Ministero dello Sviluppo Economico; Fundação de Amparo à Pesquisa do Estado de São Paulo; Conselho Nacional de Desenvolvimento Científico e Tecnológico; Ontario Ministry of Economic Development and Innovation; Genome Canada; Wellcome Trust; GlaxoSmithKline; Pfizer; Eli Lilly and Company","keywords":"Biology; DNA damage; Cell biology; Kinase; Ciliogenesis; Interactome; Cilium; G2-M DNA damage checkpoint; DNA repair; CHEK1; Protein kinase domain; Proteostasis; DNA; Genetics; Cancer; Cell cycle checkpoint; Cell cycle; Mutant; Gene","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004322283,0.000178529,0.0001426275,0.00007153014,0.0003190146,0.0004653831,0.000227426,0.0001349186,0.00007206709],"category_scores_gemma":[0.0003036587,0.000159313,0.00006056553,0.00005377164,0.00009615307,0.00001831414,0.0004317894,0.00008624693,0.00001058926],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001644516,"about_ca_system_score_gemma":0.00006023535,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000003700865,"about_ca_topic_score_gemma":0.0001163035,"domain_scores_codex":[0.9982807,0.00003250518,0.0002658573,0.0008895835,0.0002480228,0.0002833067],"domain_scores_gemma":[0.9980289,0.000002428335,0.0002232336,0.001446786,0.0001145345,0.0001840811],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003401859,0.00001505965,0.0006658948,0.00001945382,0.00001073434,0.0002914591,0.000133612,0.000003175183,0.9972321,0.00001911129,0.0002690372,0.001306346],"study_design_scores_gemma":[0.0001829751,0.0001323582,0.008746208,0.00006727965,0.000009537162,0.0002340048,0.00003924574,0.00002737373,0.9752923,0.003417572,0.01156274,0.0002883518],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9968634,0.0001857453,0.0001049602,0.0001302534,0.002013673,0.0005148509,0.00002280031,0.0000172713,0.0001470417],"genre_scores_gemma":[0.9939296,6.86395e-7,0.001773571,0.00004660938,0.00007157367,0.00005475927,0.00006332055,0.0000234979,0.004036348],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02193975,"threshold_uncertainty_score":0.6496597,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.004777589282881584,"score_gpt":0.2439179622818265,"score_spread":0.2391403729989449,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}