{"id":"W2734515449","doi":"10.1016/j.ymthe.2017.07.004","title":"Long-Duration Complete Remissions of Diffuse Large B Cell Lymphoma after Anti-CD19 Chimeric Antigen Receptor T Cell Therapy","year":2017,"lang":"en","type":"article","venue":"Molecular Therapy","topic":"CAR-T cell therapy research","field":"Medicine","cited_by":280,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"Research and Development; Graduate Women – New South Wales; Northwest University; Department of Health and Social Care; NIH Clinical Center; National Cancer Institute; National Institutes of Health; U.S. Department of Health and Human Services; Government of Canada; Geoffrey Beene Cancer Research Center; National Institute for Health and Care Research; National Cancer Research Institute","keywords":"Chimeric antigen receptor; CD19; Lymphoma; Medicine; Antigen; Receptor; Immunology; B cell; Cell; Cancer research; Biology; T cell; Antibody; Internal medicine; Immune system","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0004459816,0.0004123437,0.0006724916,0.0002170534,0.0003661113,0.0001199203,0.0005951587,0.0002346456,0.003303402],"category_scores_gemma":[0.00003686666,0.0003431949,0.0004338739,0.0002186155,0.0002380022,0.000147556,0.0001118197,0.0002593802,0.0001510668],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00008287132,"about_ca_system_score_gemma":0.0001911645,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001049977,"about_ca_topic_score_gemma":0.000003879043,"domain_scores_codex":[0.9971335,0.0002462933,0.0005291575,0.0006147669,0.00081201,0.0006642688],"domain_scores_gemma":[0.996892,0.00005344045,0.0003850145,0.002100952,0.0002626045,0.0003059627],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001682501,0.00301592,0.01856106,0.00005066703,0.000155317,0.0001377109,0.0006138217,8.533669e-7,0.9609182,0.000008482669,0.000364437,0.01449106],"study_design_scores_gemma":[0.01835688,0.0006894323,0.09450651,0.00007687023,0.00002062369,0.00001489866,0.00004722856,0.0001472384,0.8258918,0.00003034974,0.05988183,0.0003363382],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9896389,0.004138137,0.001048121,0.000782164,0.0002253293,0.001269292,0.00005892547,0.00007234402,0.002766743],"genre_scores_gemma":[0.9841714,0.009282957,0.0006619592,0.0007997698,0.0001667544,0.00007353735,0.0001231404,0.0001459613,0.004574526],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1350264,"threshold_uncertainty_score":0.999902,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02657168721673962,"score_gpt":0.3032861052003658,"score_spread":0.2767144179836261,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}