{"id":"W2734515449","doi":"10.1016/j.ymthe.2017.07.004","title":"Long-Duration Complete Remissions of Diffuse Large B Cell Lymphoma after Anti-CD19 Chimeric Antigen Receptor T Cell Therapy","year":2017,"lang":"en","type":"article","venue":"Molecular Therapy","topic":"CAR-T cell therapy research","field":"Medicine","cited_by":280,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"Research and Development; Graduate Women – New South Wales; Northwest University; Department of Health and Social Care; NIH Clinical Center; National Cancer Institute; National Institutes of Health; U.S. Department of Health and Human Services; Government of Canada; Geoffrey Beene Cancer Research Center; National Institute for Health and Care Research; National Cancer Research Institute","keywords":"Chimeric antigen receptor; CD19; Lymphoma; Medicine; Antigen; Receptor; Immunology; B cell; Cell; Cancer research; Biology; T cell; Antibody; Internal medicine; Immune system","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0008643541,0.0004929573,0.001443908,0.0003724741,0.0006457554,0.0003862338,0.0004465918,0.0009310454,0.001541943],"category_scores_gemma":[0.001013563,0.0002150689,0.0009524907,0.0003895337,0.0004546363,0.0005637511,0.0003983221,0.001893857,0.0006009226],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005777514,"about_ca_system_score_gemma":0.0003374423,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008891468,"about_ca_topic_score_gemma":0.001729544,"domain_scores_codex":[0.9995998,0.00006359151,0.0000405096,0.00005511875,0.00006062051,0.0001804278],"domain_scores_gemma":[0.9987243,0.0004406428,0.0001978141,0.0001857064,0.00005289746,0.0003986341],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"observational","study_design_scores_codex":[0.075038,0.01089651,0.0620462,0.001914064,0.002207319,0.1007406,0.001413451,0.007119655,0.1790522,0.003795987,0.009437323,0.5463387],"study_design_scores_gemma":[0.0167397,0.1217824,0.5465419,0.0002988222,0.002838555,0.1706581,0.0004742013,0.008057553,0.06334949,0.004226672,0.06478031,0.000252334],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9649189,0.01733384,0.005302717,0.001560474,0.0004070473,0.0002721617,0.0009490766,0.0002869993,0.008968764],"genre_scores_gemma":[0.9934866,0.001191329,0.0002866344,0.0006344339,0.00015061,0.00005421351,0.0008566394,0.00003411724,0.003305325],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001541943,"threshold_uncertainty_score":0.005158305,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02657168721673962,"score_gpt":0.3032861052003658,"score_spread":0.2767144179836261,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}