{"id":"W2734540391","doi":"10.1038/nrm.2017.60","title":"Genes and molecular pathways underpinning ciliopathies","year":2017,"lang":"en","type":"review","venue":"Nature Reviews Molecular Cell Biology","topic":"Genetic and Kidney Cyst Diseases","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1688,"is_retracted":false,"has_abstract":false,"ca_institutions":"Simon Fraser University","funders":"Eunice Kennedy Shriver National Institute of Child Health and Human Development; National Institute of Arthritis and Musculoskeletal and Skin Diseases; National Institute of Diabetes and Digestive and Kidney Diseases; National Institute of General Medical Sciences; Canadian Institutes of Health Research; National Institutes of Health; Michael Smith Health Research BC","keywords":"Ciliopathies; Cilium; Ciliopathy; Ciliogenesis; Intraflagellar transport; Biology; Cell biology; Motile cilium; Exocyst; Neuroscience; Phenotype; Genetics; Gene; Flagellum","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":{"n_in":0,"stratum":"aff_core","weight":5595.2375,"opus":{"tier":"OUT","genre":"empirical","about_ca":false,"confidence":"high","reason":"Molecular biology review of genes and pathways in ciliopathies; domain science."},"gpt":{"tier":"OUT","genre":"other","about_ca":false,"confidence":"high","reason":"This review concerns genes and molecular pathways in ciliopathies, not research."},"grok":{"tier":"OUT","genre":"conceptual","about_ca":false,"confidence":"high","reason":"Molecular biology review of ciliopathy genes and pathways."}},"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006066334,0.001034345,0.001421589,0.001787206,0.0002984264,0.001241353,0.001106267,0.001432557,0.002053089],"category_scores_gemma":[0.0007667968,0.0003586556,0.0004225294,0.001604232,0.001196459,0.001201494,0.001162155,0.002762486,0.001278757],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008451,"about_ca_system_score_gemma":0.001597058,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001335412,"about_ca_topic_score_gemma":0.00269857,"domain_scores_codex":[0.9997619,0.00002938277,0.00003835412,0.00003925868,0.00009987725,0.00003117731],"domain_scores_gemma":[0.9997827,0.00009879661,0.00003076504,0.000007890401,0.00005456113,0.00002522141],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001443253,0.00004970169,0.0004244359,0.01225519,0.0001195178,0.001215641,0.0001074357,0.0008082671,0.009519846,0.01740554,0.06006887,0.8978812],"study_design_scores_gemma":[0.00002226227,0.00002190127,0.0006353226,0.002440218,0.000128461,0.001687602,0.00007664462,0.0001044748,0.00126123,0.006952931,0.9866439,0.00002491711],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0001595152,0.9973617,0.0003002021,0.0006882684,0.0004450551,0.000005772602,0.00003793776,0.00001323316,0.0009882858],"genre_scores_gemma":[0.0006649825,0.9978932,0.0002514641,0.0003699587,0.00024976,0.0000068564,0.00004969546,0.000001822914,0.0005123217],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.002053089,"threshold_uncertainty_score":0,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03696051252122351,"score_gpt":0.3335075058825498,"score_spread":0.2965469933613263,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}