{"id":"W2734627099","doi":"10.1038/s41467-017-00031-7","title":"Large meta-analysis of genome-wide association studies identifies five loci for lean body mass","year":2017,"lang":"en","type":"review","venue":"Nature Communications","topic":"Genetic Associations and Epidemiology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":187,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University Medical Centre; McGill University","funders":"National Center for Advancing Translational Sciences; U.S. National Library of Medicine; National Institute of Neurological Disorders and Stroke; National Institute of Diabetes and Digestive and Kidney Diseases; National Institute on Aging; Münchner Zentrum für Gesundheitswissenschaften; Korea Centers for Disease Control and Prevention; National Health and Medical Research Council; Canadian Institutes of Health Research; School of Medicine, Johns Hopkins University; National Center for Research Resources; National Institute of General Medical Sciences; Centers for Disease Control and Prevention; National Institutes of Health; Army Research Office; Universität Greifswald; Chinese Society of Clinical Oncology; Medical Research Council; Uppsala Universitet; National Institute of Arthritis and Musculoskeletal and Skin Diseases; Greta och Johan Kocks stiftelser; Göteborgs Läkaresällskap; Sydäntutkimussäätiö; Akademiska Sjukhuset; Vetenskapsrådet; U.S. Department of Health and Human Services; GlaxoSmithKline; Signe ja Ane Gyllenbergin Säätiö; Centre for Medical Systems Biology; Genome Canada; Novo Nordisk; FP7 People: Marie-Curie Actions; American Diabetes Association; Vrije Universiteit Amsterdam; Karen Elise Jensens Fond; Svenska Läkaresällskapet; Deutsche Forschungsgemeinschaft; Nederlandse Organisatie voor Wetenschappelijk Onderzoek; British Heart Foundation; Bundesministerium für Bildung und Forschung; Johns Hopkins University; Universität zu Lübeck; King's College London; Academy of Finland; Ministerie van Economische Zaken, Landbouw en Innovatie; Diabetestutkimussäätiö; ZonMw; Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung; Nederlandse Zuivel Organisatie; Erasmus Medisch Centrum; Max-Planck-Institut für Bildungsforschung; Stiftelsen för Strategisk Forskning; Versus Arthritis; Healthway; Malmö Högskola; European Science Foundation; National Human Genome Research Institute; Danmarks Frie Forskningsfond; Kidney Research UK; Royal Society; National Institute for Health and Care Research; Wageningen University and Research; Cancer Research UK; Wellcome Trust; National Heart, Lung, and Blood Institute; Itä-Suomen Yliopisto; Foundation for Cardiovascular Research; Finska Läkaresällskapet; Yrjö Jahnssonin Säätiö; AstraZeneca; European Commission; Helsingin Yliopisto; School of Medicine, Boston University; Chronic Disease Research Foundation; Kuopion Yliopistollinen Sairaala; Wake Forest University; Scottish Government; Hjartavernd; Illinois Department of Public Health; Cedars-Sinai Medical Center; Ministry of Cultural Affairs; Emil Aaltosen Säätiö; National Science Foundation; Juho Vainion Säätiö; Novo Nordisk Fonden; American Heart Association","keywords":"Genome-wide association study; Genetics; Biology; Genome; Computational biology; Meta-analysis; Association (psychology); Medicine; Gene; Genotype; Single-nucleotide polymorphism; Psychology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":["metaepi_broad"],"consensus_categories":[],"category_scores_codex":[0.002716945,0.001205715,0.003528465,0.003305866,0.0001904974,0.001249725,0.001245478,0.0009956022,0.002224552],"category_scores_gemma":[0.003462257,0.0004215839,0.002252597,0.004116442,0.0004064076,0.0004849748,0.0007254304,0.001185462,0.0005439241],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000667463,"about_ca_system_score_gemma":0.001361501,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001807151,"about_ca_topic_score_gemma":0.003406801,"domain_scores_codex":[0.9990939,0.000291305,0.0001253469,0.000207974,0.0002344817,0.00004699798],"domain_scores_gemma":[0.9977744,0.001463906,0.0003499983,0.00007544017,0.000246507,0.00008973996],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"meta_analysis","study_design_scores_codex":[0.001075698,0.00006171838,0.02297221,0.05591285,0.0321004,0.000915864,0.00007015459,0.001259036,0.001751697,0.002245136,0.0205514,0.861084],"study_design_scores_gemma":[0.001123792,0.001076892,0.2253049,0.05498753,0.1534115,0.01184251,0.0004007663,0.002775679,0.00492924,0.01823131,0.5255422,0.0003736465],"study_design_candidate":"meta_analysis","study_design_consensus":null,"genre_codex":"review","genre_gemma":"empirical","genre_scores_codex":[0.000554905,0.9985059,0.0003093918,0.0002403483,0.00008423679,0.000005206128,0.00007375014,0.00001129225,0.000214896],"genre_scores_gemma":[0.01154962,0.9871955,0.0004707694,0.0001973275,0.0002202475,0.00001718403,0.0001683034,0.000006095681,0.000174896],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.9964715,"threshold_uncertainty_score":0.01436877,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1592543912173638,"score_gpt":0.4488504785944901,"score_spread":0.2895960873771263,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). 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