{"id":"W2734627099","doi":"10.1038/s41467-017-00031-7","title":"Large meta-analysis of genome-wide association studies identifies five loci for lean body mass","year":2017,"lang":"en","type":"review","venue":"Nature Communications","topic":"Genetic Associations and Epidemiology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":187,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University Medical Centre; McGill University","funders":"National Center for Advancing Translational Sciences; U.S. National Library of Medicine; National Institute of Neurological Disorders and Stroke; National Institute of Diabetes and Digestive and Kidney Diseases; National Institute on Aging; Münchner Zentrum für Gesundheitswissenschaften; Korea Centers for Disease Control and Prevention; National Health and Medical Research Council; Canadian Institutes of Health Research; School of Medicine, Johns Hopkins University; National Center for Research Resources; National Institute of General Medical Sciences; Centers for Disease Control and Prevention; National Institutes of Health; Army Research Office; Universität Greifswald; Chinese Society of Clinical Oncology; Medical Research Council; Uppsala Universitet; National Institute of Arthritis and Musculoskeletal and Skin Diseases; Greta och Johan Kocks stiftelser; Göteborgs Läkaresällskap; Sydäntutkimussäätiö; Akademiska Sjukhuset; Vetenskapsrådet; U.S. Department of Health and Human Services; GlaxoSmithKline; Signe ja Ane Gyllenbergin Säätiö; Centre for Medical Systems Biology; Genome Canada; Novo Nordisk; FP7 People: Marie-Curie Actions; American Diabetes Association; Vrije Universiteit Amsterdam; Karen Elise Jensens Fond; Svenska Läkaresällskapet; Deutsche Forschungsgemeinschaft; Nederlandse Organisatie voor Wetenschappelijk Onderzoek; British Heart Foundation; Bundesministerium für Bildung und Forschung; Johns Hopkins University; Universität zu Lübeck; King's College London; Academy of Finland; Ministerie van Economische Zaken, Landbouw en Innovatie; Diabetestutkimussäätiö; ZonMw; Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung; Nederlandse Zuivel Organisatie; Erasmus Medisch Centrum; Max-Planck-Institut für Bildungsforschung; Stiftelsen för Strategisk Forskning; Versus Arthritis; Healthway; Malmö Högskola; European Science Foundation; National Human Genome Research Institute; Danmarks Frie Forskningsfond; Kidney Research UK; Royal Society; National Institute for Health and Care Research; Wageningen University and Research; Cancer Research UK; Wellcome Trust; National Heart, Lung, and Blood Institute; Itä-Suomen Yliopisto; Foundation for Cardiovascular Research; Finska Läkaresällskapet; Yrjö Jahnssonin Säätiö; AstraZeneca; European Commission; Helsingin Yliopisto; School of Medicine, Boston University; Chronic Disease Research Foundation; Kuopion Yliopistollinen Sairaala; Wake Forest University; Scottish Government; Hjartavernd; Illinois Department of Public Health; Cedars-Sinai Medical Center; Ministry of Cultural Affairs; Emil Aaltosen Säätiö; National Science Foundation; Juho Vainion Säätiö; Novo Nordisk Fonden; American Heart Association","keywords":"Genome-wide association study; Genetics; Biology; Genome; Computational biology; Meta-analysis; Association (psychology); Medicine; Gene; Genotype; Single-nucleotide polymorphism; Psychology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaresearch","metaepi_narrow","research_integrity"],"consensus_categories":[],"category_scores_codex":[0.002100636,0.0003464165,0.003107237,0.00026791,0.0005456464,0.00003252033,0.001773181,0.001345396,0.00001280725],"category_scores_gemma":[0.01011715,0.0002887889,0.003510188,0.0002892379,0.0001210765,0.000005414056,0.000638945,0.00055631,0.000005917862],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000131629,"about_ca_system_score_gemma":0.0001773606,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001037786,"about_ca_topic_score_gemma":0.001451398,"domain_scores_codex":[0.9975282,0.000593366,0.0009519301,0.0004516766,0.0001626324,0.0003121831],"domain_scores_gemma":[0.9911033,0.002078128,0.002560146,0.003191621,0.001020075,0.00004673239],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"meta_analysis","study_design_gemma":"not_applicable","study_design_scores_codex":[0.000006393933,0.0002224174,0.001574316,0.001530447,0.8967471,2.723719e-7,0.000196595,0.00006697208,0.00002515244,0.001056801,0.09582482,0.002748699],"study_design_scores_gemma":[0.00007732411,0.00002468741,0.000329541,0.00002256812,0.2093543,1.797857e-7,0.00008422567,0.00001765869,0.000002192641,0.0001817032,0.7897101,0.0001954522],"study_design_candidate":"meta_analysis","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.00001481513,0.9948752,0.0005163234,0.0008881828,0.000130292,0.0007355422,0.00253365,0.000009932182,0.0002960547],"genre_scores_gemma":[0.001523956,0.9758388,0.003065856,0.000222368,0.00008590353,0.0006208745,0.01206321,0.00003559247,0.006543411],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.6938853,"threshold_uncertainty_score":0.9999564,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1592543912173638,"score_gpt":0.4488504785944901,"score_spread":0.2895960873771263,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). 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