{"id":"W2734664868","doi":"10.1093/cercor/bhx180","title":"Notch Activation by Shootin1 Opposing Activities on 2 Ubiquitin Ligases","year":2017,"lang":"en","type":"article","venue":"Cerebral Cortex","topic":"Developmental Biology and Gene Regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":11,"is_retracted":false,"has_abstract":true,"ca_institutions":"SickKids Foundation; Hospital for Sick Children; University of Toronto","funders":"Israel Science Foundation; Helen and Martin Kimmel Institute for Stem Cell Research, Weizmann Institute of Science; Minerva Foundation; Fondation Jérôme Lejeune","keywords":"Notch signaling pathway; Notch proteins; Ubiquitin; NUMB; Cell biology; Hes3 signaling axis; Cell fate determination; Ubiquitin ligase; Transcription factor; Signal transduction; Biology; Transmembrane protein; Chemistry; Receptor; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001612934,0.0003835981,0.0002718901,0.0002045566,0.0002185223,0.0004861535,0.0001463249,0.0002002948,0.001572714],"category_scores_gemma":[0.00006072351,0.0001342767,0.0003071211,0.0001190263,0.0001610352,0.0002502951,0.0003891725,0.0002260071,0.0003618882],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005903069,"about_ca_system_score_gemma":0.000195431,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004238543,"about_ca_topic_score_gemma":0.001007341,"domain_scores_codex":[0.9998279,0.00001878938,0.00001316368,0.0000519271,0.00003759106,0.00005075043],"domain_scores_gemma":[0.9999362,0.000006269359,0.00002239817,0.00000678019,0.000008626578,0.0000196964],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002422628,0.00001478113,0.001266053,0.00004122768,0.00001278955,0.00008125683,0.00001942255,0.0001429735,0.9947408,0.00049336,0.00005865467,0.002886458],"study_design_scores_gemma":[0.0000182219,0.00008988041,0.01216526,0.000006909358,0.00001709892,0.0004416645,0.00004043935,0.001197232,0.9827868,0.0001714113,0.003057896,0.000007128127],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9927757,0.00262988,0.002117044,0.00006780931,0.00001402715,0.00001117304,0.0001936459,0.00004257188,0.002147975],"genre_scores_gemma":[0.9931847,0.001119068,0.001215009,0.00003563346,0.00000761518,0.00001315474,0.0002656744,0.0000105115,0.00414864],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001572714,"threshold_uncertainty_score":0.005261302,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01188134671382647,"score_gpt":0.2646428139269807,"score_spread":0.2527614672131542,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}