{"id":"W2734664868","doi":"10.1093/cercor/bhx180","title":"Notch Activation by Shootin1 Opposing Activities on 2 Ubiquitin Ligases","year":2017,"lang":"en","type":"article","venue":"Cerebral Cortex","topic":"Developmental Biology and Gene Regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":11,"is_retracted":false,"has_abstract":true,"ca_institutions":"SickKids Foundation; Hospital for Sick Children; University of Toronto","funders":"Israel Science Foundation; Helen and Martin Kimmel Institute for Stem Cell Research, Weizmann Institute of Science; Minerva Foundation; Fondation Jérôme Lejeune","keywords":"Notch signaling pathway; Notch proteins; Ubiquitin; NUMB; Cell biology; Hes3 signaling axis; Cell fate determination; Ubiquitin ligase; Transcription factor; Signal transduction; Biology; Transmembrane protein; Chemistry; Receptor; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00007212062,0.0001300034,0.00009650039,0.0000206613,0.0004132483,0.00006400612,0.0001694882,0.0001507872,0.00003743003],"category_scores_gemma":[0.00005549301,0.000123161,0.00004730932,0.00001554233,0.0001011777,0.00001409457,0.00008810925,0.00006669745,0.00001895392],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001764104,"about_ca_system_score_gemma":0.00003562499,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001312261,"about_ca_topic_score_gemma":0.00001656923,"domain_scores_codex":[0.9993308,0.0000276858,0.000110433,0.0002788764,0.00007649577,0.0001757783],"domain_scores_gemma":[0.9994985,0.000009400544,0.000124728,0.0002990006,0.00002261985,0.00004567743],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001052404,0.00003448266,0.008787891,0.00000565573,0.00002551586,5.494059e-7,0.00001689222,0.000002055947,0.9631063,0.00009077159,0.00634485,0.02147979],"study_design_scores_gemma":[0.0002644349,0.0001618948,0.1004232,0.00002013811,0.000005117062,0.000003771894,0.00003941325,0.00001128723,0.888979,0.00006253611,0.009874462,0.0001547811],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9928249,0.0000453258,0.0001585673,0.0003981759,0.0002021834,0.0001070513,0.00001741783,0.00001531364,0.006231102],"genre_scores_gemma":[0.9940817,0.00002470861,0.0001143138,0.0004077284,0.0001817295,0.00001078852,0.0004220741,0.00001323677,0.004743728],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.09163533,"threshold_uncertainty_score":0.5022359,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01188134671382647,"score_gpt":0.2646428139269807,"score_spread":0.2527614672131542,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}